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• W2074304510 startingPage "3451" @default.
• W2074304510 abstract "Chemical reactions in cells are subject to intense stochastic fluctuations. An important question is how the fundamental physiological behavior of the cell is kept stable against those noisy perturbations. In this study, a stochastic model of the cell cycle of budding yeast was constructed to analyze the effects of noise on the cell-cycle oscillation. The model predicts intense noise in levels of mRNAs and proteins, and the simulated protein levels explain the observed statistical tendency of noise in populations of synchronous and asynchronous cells. Despite intense noise in levels of proteins and mRNAs, the cell cycle is stable enough to bring the largely perturbed cells back to the physiological cyclic oscillation. The model shows that consecutively appearing fixed points are the origin of this stability of the cell cycle." @default.
• W2074304510 created "2016-06-24" @default.
• W2074304510 creator A5016751632 @default.
• W2074304510 creator A5070740988 @default.
• W2074304510 date "2007-11-01" @default.
• W2074304510 modified "2023-10-14" @default.
• W2074304510 title "Stable Stochastic Dynamics in Yeast Cell Cycle" @default.
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• W2074304510 doi "https://doi.org/10.1529/biophysj.107.109991" @default.
• W2074304510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2072056" @default.
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• W2074304510 hasPublicationYear "2007" @default.
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