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• W2074304888 abstract "The motivation of this study is to understand the experimental observations of different responses of cell on stretched substrate to the static and dynamic loads. In this talk, a focal adhesion model which can consider the mechanics of stress fiber, adhesion bonds, and substrate is developed at molecular level by treating the focal adhesion as an adhesion cluster. The stability of the cluster under dynamic load is studied by applying cyclic external strain on the substrate. We show that there exists a threshold value of external strain amplitude, beyond which the adhesion cluster disrupts quickly. In addition, our results show that the adhesion cluster is prone to losing stability under high-frequency loading, because the receptors and ligands can not get enough contact time to form bonds due to the high-speed deformation of the substrate, and at the same time the viscoelastic stress fiber becomes rigid at high-frequency which attributes large deformation to the bonds. Furthermore, we find that the stiffness of stress fiber takes an important role in the stability of the adhesion cluster. The essence of this work is to connect the dynamics of the adhesion bonds (molecular levels) with the behaviors of the reorientation of cell (cell level) through mechanics of stress fiber. The predictions of our cluster model are broadly consistent with the experimental results." @default.
• W2074304888 created "2016-06-24" @default.
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• W2074304888 date "2009-02-01" @default.
• W2074304888 modified "2023-09-27" @default.
• W2074304888 title "Modeling of Stability of Adhesion Clusters and Cell Reorientation under Lateral Dynamics Load" @default.
• W2074304888 doi "https://doi.org/10.1016/j.bpj.2008.12.2696" @default.
• W2074304888 hasPublicationYear "2009" @default.
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