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- W2074306073 abstract "In 1984, CILAG initiated the development of a topical formulation containing liposomes. Driven by the conviction that liposomally entrapped econazole might have beneficial clinical properties, a manufacturing technique with potential for economic scale-up was developed. The liposomes were produced by the ethanol injection technique on a scale of several hundred kilograms per batch in a commercially viable way. The use of hazardous solvents, detergents or other critical raw materials was avoided. The size, encapsulation rate, lamellarity, and stability were well controlled and reproducible. Clinical investigations resulted in a quicker onset of effect because of increased active drug substance level in the stratum corneum. In addition, the treatment duration is usually reduced. Pevaryl® Lipogel became the first approved liposome dermatic and proved the feasibility of liposomal systems." @default.
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- W2074306073 date "1996-02-01" @default.
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- W2074306073 title "Feasibility of topical liposome drugs produced on an industrial scale" @default.
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