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- W2074307774 abstract "Significance The ventromedial nucleus of the hypothalamus (VMH) plays an important role in the regulation of glucose metabolism. Here we show that prolyl endopeptidase (PREP), a serine protease, is expressed in the VMH where it functions to regulate glucose-induced insulin secretion. Experimental knockdown of central PREP induced impairment of VMH glucose sensing, resulting in reduced insulin and increased glucagon secretion by the pancreas via altered sympathetic outflow. Our data reveal PREP as a new hypothalamic player in the control of glucose homeostasis." @default.
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- W2074307774 date "2014-07-28" @default.
- W2074307774 modified "2023-10-16" @default.
- W2074307774 title "Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice" @default.
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- W2074307774 doi "https://doi.org/10.1073/pnas.1406000111" @default.
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