Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074308001> ?p ?o ?g. }
- W2074308001 endingPage "140" @default.
- W2074308001 startingPage "129" @default.
- W2074308001 abstract "High-mobility group box 1 (HMGB1) proteins are substantially up-regulated in acute and chronic hepatitis. However, the immunopathogenic role of HMGB1 in patients with chronic hepatitis B (CHB) has not been elucidated. In this study, using a cohort of 36 CHB patients, we demonstrated a crucial role for HMGB1 to modulate balance between regulatory T (Treg) and T helper 17 (Th17) cells via the toll-like receptor (TLR)-4-interleukin (IL)-6 pathway. Serum HMGB1 levels were dramatically higher in CHB patients and increased along with liver injury, inflammation and fibrosis. Notably, HMGB1 increased along with decreased Treg/Th17 cells ratios in the periphery or intrahepatic microenvironment, which provides a clue for HMGB1 to favour Th17 responses whereas inhibit Treg responses. For in vitro studies, serum pools were constructed with serum from CHB patients at an advanced stage, whereas peripheral blood mononuclear cells (PBMC) pools were constructed with cells from those at an early stage. CHB-serum significantly enhanced retinoic acid-related orphan receptor-γt (RORγt), whereas they inhibited forkhead box P3 (Foxp3) expression in CHB-PBMC, which could be reversed by blocking of HMGB1, TLR4, or IL-6. Besides, recombinant HMGB1 (rHMGB1) dose-dependently up-regulated RORγt whereas down-regulated Foxp3 expression in CHB-PBMC, and meanwhile, rHMGB1 enhanced TLR4 and IL-6 expression in CHB-PBMC. Moreover, the axis of HMGB1–TLR4-IL-6–Treg/Th17 required noncontact interactions between CD4 and non-CD4 cells. In addition, rHMGB1 down-regulated anti-inflammatory proteins on CD4+CD25+ cells whereas up-regulated pro-inflammatory cytokines in CD4+CD25− cells. In summary, enriched HMGB1 in CHB patients shifts Treg/Th17 balance to Th17 dominance via the TLR4-IL-6 pathway, which exacerbates liver injury and inflammation." @default.
- W2074308001 created "2016-06-24" @default.
- W2074308001 creator A5000756875 @default.
- W2074308001 creator A5002397146 @default.
- W2074308001 creator A5018411968 @default.
- W2074308001 creator A5033351279 @default.
- W2074308001 creator A5046813246 @default.
- W2074308001 creator A5075764059 @default.
- W2074308001 creator A5081084797 @default.
- W2074308001 creator A5091729335 @default.
- W2074308001 date "2013-08-25" @default.
- W2074308001 modified "2023-10-14" @default.
- W2074308001 title "Enhanced high-mobility group box 1 (HMGB1) modulates regulatory T cells (Treg)/T helper 17 (Th17) balance via toll-like receptor (TLR)-4-interleukin (IL)-6 pathway in patients with chronic hepatitis B" @default.
- W2074308001 cites W1565588031 @default.
- W2074308001 cites W1842438189 @default.
- W2074308001 cites W1969981758 @default.
- W2074308001 cites W1985528704 @default.
- W2074308001 cites W1986904544 @default.
- W2074308001 cites W1991744568 @default.
- W2074308001 cites W1991799969 @default.
- W2074308001 cites W2007466030 @default.
- W2074308001 cites W2008875301 @default.
- W2074308001 cites W2012201060 @default.
- W2074308001 cites W2014732588 @default.
- W2074308001 cites W2018653121 @default.
- W2074308001 cites W2021227765 @default.
- W2074308001 cites W2025335044 @default.
- W2074308001 cites W2031188093 @default.
- W2074308001 cites W2035462578 @default.
- W2074308001 cites W2044951291 @default.
- W2074308001 cites W2047744633 @default.
- W2074308001 cites W2048056516 @default.
- W2074308001 cites W2053851195 @default.
- W2074308001 cites W2059158081 @default.
- W2074308001 cites W2087949560 @default.
- W2074308001 cites W2097391811 @default.
- W2074308001 cites W2100853445 @default.
- W2074308001 cites W2104614292 @default.
- W2074308001 cites W2123140856 @default.
- W2074308001 cites W2135131688 @default.
- W2074308001 cites W2147009888 @default.
- W2074308001 cites W2153456420 @default.
- W2074308001 cites W2159670163 @default.
- W2074308001 cites W2159954692 @default.
- W2074308001 cites W2166849716 @default.
- W2074308001 doi "https://doi.org/10.1111/jvh.12152" @default.
- W2074308001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24383926" @default.
- W2074308001 hasPublicationYear "2013" @default.
- W2074308001 type Work @default.
- W2074308001 sameAs 2074308001 @default.
- W2074308001 citedByCount "62" @default.
- W2074308001 countsByYear W20743080012014 @default.
- W2074308001 countsByYear W20743080012015 @default.
- W2074308001 countsByYear W20743080012016 @default.
- W2074308001 countsByYear W20743080012017 @default.
- W2074308001 countsByYear W20743080012018 @default.
- W2074308001 countsByYear W20743080012019 @default.
- W2074308001 countsByYear W20743080012020 @default.
- W2074308001 countsByYear W20743080012021 @default.
- W2074308001 countsByYear W20743080012022 @default.
- W2074308001 countsByYear W20743080012023 @default.
- W2074308001 crossrefType "journal-article" @default.
- W2074308001 hasAuthorship W2074308001A5000756875 @default.
- W2074308001 hasAuthorship W2074308001A5002397146 @default.
- W2074308001 hasAuthorship W2074308001A5018411968 @default.
- W2074308001 hasAuthorship W2074308001A5033351279 @default.
- W2074308001 hasAuthorship W2074308001A5046813246 @default.
- W2074308001 hasAuthorship W2074308001A5075764059 @default.
- W2074308001 hasAuthorship W2074308001A5081084797 @default.
- W2074308001 hasAuthorship W2074308001A5091729335 @default.
- W2074308001 hasConcept C136449434 @default.
- W2074308001 hasConcept C137061746 @default.
- W2074308001 hasConcept C202751555 @default.
- W2074308001 hasConcept C203014093 @default.
- W2074308001 hasConcept C2776070231 @default.
- W2074308001 hasConcept C2776090121 @default.
- W2074308001 hasConcept C2776709828 @default.
- W2074308001 hasConcept C2776914184 @default.
- W2074308001 hasConcept C2778690821 @default.
- W2074308001 hasConcept C2779727006 @default.
- W2074308001 hasConcept C2780545709 @default.
- W2074308001 hasConcept C55493867 @default.
- W2074308001 hasConcept C71924100 @default.
- W2074308001 hasConcept C74172505 @default.
- W2074308001 hasConcept C74737994 @default.
- W2074308001 hasConcept C79484868 @default.
- W2074308001 hasConcept C86803240 @default.
- W2074308001 hasConcept C8891405 @default.
- W2074308001 hasConceptScore W2074308001C136449434 @default.
- W2074308001 hasConceptScore W2074308001C137061746 @default.
- W2074308001 hasConceptScore W2074308001C202751555 @default.
- W2074308001 hasConceptScore W2074308001C203014093 @default.
- W2074308001 hasConceptScore W2074308001C2776070231 @default.
- W2074308001 hasConceptScore W2074308001C2776090121 @default.
- W2074308001 hasConceptScore W2074308001C2776709828 @default.
- W2074308001 hasConceptScore W2074308001C2776914184 @default.
- W2074308001 hasConceptScore W2074308001C2778690821 @default.
- W2074308001 hasConceptScore W2074308001C2779727006 @default.