Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074309612> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2074309612 abstract "We have previously demonstrated that the simultaneous presence of alpha-melanocyte stimulating hormone (alpha-MSH) and dopamine resulted in a reduction in cyclic AMP (cAMP) levels in slices containing caudate putamen and accumbens nuclei as compared to those treated only with dopamine or alpha-MSH. This study was carried out to explore if the interaction between alpha-MSH and dopamine could be explained on the basis of a direct interaction between alpha-MSH and the dopamine D1 receptor. Saturation curves for [n-methyl-3 H](R)-(+)-8 chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1 H-3-benzazepin-7-o] hemimaleate ([3H]SCH 23390) binding in the presence of increasing concentrations of alpha-MSH were performed. Nonlinear regression in the presence of alpha-MSH revealed an increased dissociation constant (Kd). The binding capacity (Bmax) was not affected by the peptide. These data suggest an apparent competitive interaction between alpha-MSH and [3H]SCH 23390 in striatal membranes on the dopamine D1 receptor; (Ki = 1.2 X 10(-7) M). The present data show that alpha-MSH could interact with the dopamine D1 receptor modulating allosterically the affinity of [3H]SCH 23390 for the receptor or by causing a change in the lipid environment of the dopamine receptor, resulting in an inhibition of the ligand binding to it." @default.
- W2074309612 created "2016-06-24" @default.
- W2074309612 creator A5048902592 @default.
- W2074309612 creator A5059305197 @default.
- W2074309612 creator A5084307981 @default.
- W2074309612 date "1998-12-01" @default.
- W2074309612 modified "2023-10-07" @default.
- W2074309612 title "α-Melanotropin hormone inhibits the binding of []SCH 23390 to the dopamine D1 receptor in vitro" @default.
- W2074309612 cites W1549372716 @default.
- W2074309612 cites W1759002262 @default.
- W2074309612 cites W1775749144 @default.
- W2074309612 cites W1964170309 @default.
- W2074309612 cites W1971842245 @default.
- W2074309612 cites W1979420492 @default.
- W2074309612 cites W1984061089 @default.
- W2074309612 cites W1991684639 @default.
- W2074309612 cites W1991789525 @default.
- W2074309612 cites W1996428017 @default.
- W2074309612 cites W1998375555 @default.
- W2074309612 cites W1999961963 @default.
- W2074309612 cites W2000313746 @default.
- W2074309612 cites W2007180342 @default.
- W2074309612 cites W2010874272 @default.
- W2074309612 cites W2022649017 @default.
- W2074309612 cites W2033217568 @default.
- W2074309612 cites W2047796233 @default.
- W2074309612 cites W2058278490 @default.
- W2074309612 cites W2058962756 @default.
- W2074309612 cites W2059714715 @default.
- W2074309612 cites W2065347051 @default.
- W2074309612 cites W2068988838 @default.
- W2074309612 cites W2071180734 @default.
- W2074309612 cites W2071938807 @default.
- W2074309612 cites W2084896194 @default.
- W2074309612 cites W2086249718 @default.
- W2074309612 cites W2088467610 @default.
- W2074309612 cites W2128164253 @default.
- W2074309612 cites W2314916637 @default.
- W2074309612 doi "https://doi.org/10.1016/s0014-2999(98)00772-9" @default.
- W2074309612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9881592" @default.
- W2074309612 hasPublicationYear "1998" @default.
- W2074309612 type Work @default.
- W2074309612 sameAs 2074309612 @default.
- W2074309612 citedByCount "9" @default.
- W2074309612 countsByYear W20743096122012 @default.
- W2074309612 countsByYear W20743096122016 @default.
- W2074309612 countsByYear W20743096122021 @default.
- W2074309612 crossrefType "journal-article" @default.
- W2074309612 hasAuthorship W2074309612A5048902592 @default.
- W2074309612 hasAuthorship W2074309612A5059305197 @default.
- W2074309612 hasAuthorship W2074309612A5084307981 @default.
- W2074309612 hasConcept C120069818 @default.
- W2074309612 hasConcept C120750228 @default.
- W2074309612 hasConcept C126322002 @default.
- W2074309612 hasConcept C134018914 @default.
- W2074309612 hasConcept C170493617 @default.
- W2074309612 hasConcept C185592680 @default.
- W2074309612 hasConcept C2779917531 @default.
- W2074309612 hasConcept C44208683 @default.
- W2074309612 hasConcept C513476851 @default.
- W2074309612 hasConcept C55493867 @default.
- W2074309612 hasConcept C71924100 @default.
- W2074309612 hasConcept C74998103 @default.
- W2074309612 hasConcept C86803240 @default.
- W2074309612 hasConceptScore W2074309612C120069818 @default.
- W2074309612 hasConceptScore W2074309612C120750228 @default.
- W2074309612 hasConceptScore W2074309612C126322002 @default.
- W2074309612 hasConceptScore W2074309612C134018914 @default.
- W2074309612 hasConceptScore W2074309612C170493617 @default.
- W2074309612 hasConceptScore W2074309612C185592680 @default.
- W2074309612 hasConceptScore W2074309612C2779917531 @default.
- W2074309612 hasConceptScore W2074309612C44208683 @default.
- W2074309612 hasConceptScore W2074309612C513476851 @default.
- W2074309612 hasConceptScore W2074309612C55493867 @default.
- W2074309612 hasConceptScore W2074309612C71924100 @default.
- W2074309612 hasConceptScore W2074309612C74998103 @default.
- W2074309612 hasConceptScore W2074309612C86803240 @default.
- W2074309612 hasLocation W20743096121 @default.
- W2074309612 hasLocation W20743096122 @default.
- W2074309612 hasOpenAccess W2074309612 @default.
- W2074309612 hasPrimaryLocation W20743096121 @default.
- W2074309612 hasRelatedWork W1970624076 @default.
- W2074309612 hasRelatedWork W1977323374 @default.
- W2074309612 hasRelatedWork W1999003861 @default.
- W2074309612 hasRelatedWork W2020871709 @default.
- W2074309612 hasRelatedWork W2040777203 @default.
- W2074309612 hasRelatedWork W2052987991 @default.
- W2074309612 hasRelatedWork W2063007301 @default.
- W2074309612 hasRelatedWork W2074309612 @default.
- W2074309612 hasRelatedWork W2093189958 @default.
- W2074309612 hasRelatedWork W74044324 @default.
- W2074309612 isParatext "false" @default.
- W2074309612 isRetracted "false" @default.
- W2074309612 magId "2074309612" @default.
- W2074309612 workType "article" @default.