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- W2074312878 abstract "Objective: To determine the effect of high-grade prostate cancer (Gleason pattern 5) on the prognosis of patients treated with Pd-103 brachytherapy. Methods: A total of 499 higher-risk patients [Gleason score 7 or higher or prostate-specific antigen (PSA) 10–20 ng/mL] treated on a prospective protocol with Pd-103 and supplemental external beam radiation were studied. All prostate biopsies were reviewed for Gleason grade by 2 pathologists (L.T. and J.V.). Along with assignment of a Gleason score based on established criteria, the presence of any pattern 5 cancer was separately noted and photographed for future review. Freedom from biochemical failure was defined as a serum PSA ≤ 0.5 ng/mL at last follow-up. Results: The biochemical control rate at 3 years for all 499 patients was 86%, with 348 patients followed beyond that time. Patients without pattern 5 cancer had an 89% rate of biochemical control at 3 years, versus 72% in the 87 patients with pattern 5 cancer (P = 0.0001). In Cox multivariate regression analysis, which included Gleason score, highest Gleason pattern, and pretreatment PSA, the Gleason score was the single most important predictor of biochemical control (P < 0.0001). Conclusion: The presence of pattern 5 disease is a risk factor for biochemical failure. But in sharp contrast to prior studies, Pd-103 brachytherapy-based radiation appears to provide such patients with a high likelihood of cancer eradication." @default.
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- W2074312878 date "2007-12-01" @default.
- W2074312878 modified "2023-09-25" @default.
- W2074312878 title "The Prognostic Significance of Gleason Pattern 5 in Prostate Cancer Patients Treated With Pd-103 Brachytherapy" @default.
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- W2074312878 doi "https://doi.org/10.1097/coc.0b013e318145b9ba" @default.
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