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- W2074313718 abstract "Letters, Comments, and Corrections1 January 1973Triiodothyronine in DiagnosisJOEL I. HAMBURGER, M.D.JOEL I. HAMBURGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-1-156 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Shenkman and associates (1) remind us that an elevated serum triiodothyronine (T3) concentration need not mean hyperthyroidism. Nonsuppressible 24-hour131I uptake may be seen ineuthyroidpatients with autonomously functioning adenomas, multinodular goiter, or Graves's disease. Thus the principal laboratory criteria for the diagnosis of T3toxicosis are not specific for hyperthyroidism. Shenkman's 10 patients seem bona fide, since all have elevated131I uptake values and histories of previous toxicity. Patients in other published cases have had normal uptake values, non-suppressible, to be sure, with diagnosis based chiefly on the elevated serum T3level (2). Since elevated...References1. SHENKMANMITSUMABLUM LTM: Recurrent hyperthyroidism presenting as triiodothyronine toxicosis. Ann Intern Med 77:410-413, 1972 LinkGoogle Scholar2. WAHNERGORMAN HC: Interpretation of serum tri-iodothyronine levels measured by the Sterling technic. N Engl J Med 284:225-230, 1971 CrossrefMedlineGoogle Scholar3. HAMBURGER J: Hyperthyroidism—Concept and Controversy. Springfield, Ill., Charles C Thomas, Publisher, 1972, p. 28 Google Scholar1. SHENKMANMITSUMABLUM LTM: Recurrent hyperthyroidism presenting as triiodothyronine toxicosis. Ann Intern Med 77:410-413, 1972 LinkGoogle Scholar2. SHENKMANMITSUMAHOLLANDER LTC: Modulation of pituitary responsiveness to thyrotropin-releasing hormone by triiodothyronine. J Clin Invest. In press, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Northland Thyroid Laboratory Northland Medical Building Southfield, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1973Volume 78, Issue 1Page: 156-157KeywordsAdenomasAttentionHyperthyroidismResearch laboratoriesToxicityTriiodothyronine Issue Published: 1 January 1973 PDF DownloadLoading ..." @default.
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- W2074313718 title "Triiodothyronine in Diagnosis" @default.
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