FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074316110> ?p ?o ?g. }

• W2074316110 abstract "Forty-one human pituitary adenoma specimens were examined for the presence of estrogen receptor (ER) messenger ribonucleic acid and protein using a combination of ribonuclease protection assay, [3H] estradiol ([3H]E2) binding, and ER immunohistochemistry. ER messenger ribonucleic acid prevalence was high in PRL-immunoreactive tumors (2 of 2), moderate in GH/PRL tumors (2 of 5), and low or absent (0 of 4) in GH tumors. In the GH/PRL-immunostaining tumors, the presence of the ER was uniformly associated with elevated serum PRL levels. Among the gonadotropin-immunostaining tumors, 10 of 17 were ER positive; within this group, those with gonadotroph adenoma characteristics were ER positive, whereas those with null cell/oncocytic characteristics were ER negative. Of the tumors that did not immunostain for any known anterior pituitary hormones, 3 of 11 were ER positive. ER immunohistochemistry in 14 tumors revealed a 100% correlation with ribonuclease protection assay results, whereas [3H]E2 binding, determined in 9 tumors, showed an 87% correlation. In summary, it appears that PRL and a specific class of gonadotropin-immunostaining tumors (identifiable by specific characteristics on electron microscope) contain ER, whereas GH-immunostaining tumors are ER negative. ER expression in normal pituitary paralleled that in macroadenomas (GH, 2.3%; PRL, 50%; FSH, 70%; LH, 83%; TSH, 4%; ACTH, 1%). The ER-positive tumors represent a subset whose growth and secretory profiles may be influenced by the gonadal steroidal milieu or by pharmacological agents that affect E2 levels or ER function." @default.
• W2074316110 created "2016-06-24" @default.
• W2074316110 creator A5028115280 @default.
• W2074316110 creator A5030000005 @default.
• W2074316110 creator A5042552578 @default.
• W2074316110 creator A5049277382 @default.
• W2074316110 creator A5084642276 @default.
• W2074316110 creator A5089245297 @default.
• W2074316110 date "1994-06-01" @default.
• W2074316110 modified "2023-10-17" @default.
• W2074316110 title "Estrogen receptor expression in human pituitary: correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas." @default.
• W2074316110 cites W110628693 @default.
• W2074316110 cites W1503985608 @default.
• W2074316110 cites W1529149604 @default.
• W2074316110 cites W1550441131 @default.
• W2074316110 cites W1965392450 @default.
• W2074316110 cites W1983649348 @default.
• W2074316110 cites W1984183002 @default.
• W2074316110 cites W1987366224 @default.
• W2074316110 cites W1987910229 @default.
• W2074316110 cites W2001925018 @default.
• W2074316110 cites W2030144383 @default.
• W2074316110 cites W2060333964 @default.
• W2074316110 cites W2060937867 @default.
• W2074316110 cites W2071792035 @default.
• W2074316110 cites W2079738563 @default.
• W2074316110 cites W2085765294 @default.
• W2074316110 cites W2091744333 @default.
• W2074316110 cites W2092094647 @default.
• W2074316110 cites W2092107317 @default.
• W2074316110 cites W2092650102 @default.
• W2074316110 cites W2097551860 @default.
• W2074316110 cites W2166815259 @default.
• W2074316110 cites W2264534620 @default.
• W2074316110 cites W2299038488 @default.
• W2074316110 cites W2404021075 @default.
• W2074316110 doi "https://doi.org/10.1210/jcem.78.6.7515390" @default.
• W2074316110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7515390" @default.
• W2074316110 hasPublicationYear "1994" @default.
• W2074316110 type Work @default.
• W2074316110 sameAs 2074316110 @default.
• W2074316110 citedByCount "55" @default.
• W2074316110 countsByYear W20743161102012 @default.
• W2074316110 countsByYear W20743161102014 @default.
• W2074316110 countsByYear W20743161102015 @default.
• W2074316110 countsByYear W20743161102017 @default.
• W2074316110 countsByYear W20743161102019 @default.
• W2074316110 countsByYear W20743161102020 @default.
• W2074316110 countsByYear W20743161102021 @default.
• W2074316110 countsByYear W20743161102022 @default.
• W2074316110 crossrefType "journal-article" @default.
• W2074316110 hasAuthorship W2074316110A5028115280 @default.
• W2074316110 hasAuthorship W2074316110A5030000005 @default.
• W2074316110 hasAuthorship W2074316110A5042552578 @default.
• W2074316110 hasAuthorship W2074316110A5049277382 @default.
• W2074316110 hasAuthorship W2074316110A5084642276 @default.
• W2074316110 hasAuthorship W2074316110A5089245297 @default.
• W2074316110 hasConcept C121608353 @default.
• W2074316110 hasConcept C126322002 @default.
• W2074316110 hasConcept C134018914 @default.
• W2074316110 hasConcept C204232928 @default.
• W2074316110 hasConcept C2777164284 @default.
• W2074316110 hasConcept C2777428134 @default.
• W2074316110 hasConcept C2778782382 @default.
• W2074316110 hasConcept C2779029589 @default.
• W2074316110 hasConcept C4224716 @default.
• W2074316110 hasConcept C530470458 @default.
• W2074316110 hasConcept C71315377 @default.
• W2074316110 hasConcept C71924100 @default.
• W2074316110 hasConcept C84606932 @default.
• W2074316110 hasConcept C86803240 @default.
• W2074316110 hasConceptScore W2074316110C121608353 @default.
• W2074316110 hasConceptScore W2074316110C126322002 @default.
• W2074316110 hasConceptScore W2074316110C134018914 @default.
• W2074316110 hasConceptScore W2074316110C204232928 @default.
• W2074316110 hasConceptScore W2074316110C2777164284 @default.
• W2074316110 hasConceptScore W2074316110C2777428134 @default.
• W2074316110 hasConceptScore W2074316110C2778782382 @default.
• W2074316110 hasConceptScore W2074316110C2779029589 @default.
• W2074316110 hasConceptScore W2074316110C4224716 @default.
• W2074316110 hasConceptScore W2074316110C530470458 @default.
• W2074316110 hasConceptScore W2074316110C71315377 @default.
• W2074316110 hasConceptScore W2074316110C71924100 @default.
• W2074316110 hasConceptScore W2074316110C84606932 @default.
• W2074316110 hasConceptScore W2074316110C86803240 @default.
• W2074316110 hasLocation W20743161101 @default.
• W2074316110 hasLocation W20743161102 @default.
• W2074316110 hasOpenAccess W2074316110 @default.
• W2074316110 hasPrimaryLocation W20743161101 @default.
• W2074316110 hasRelatedWork W1963617861 @default.
• W2074316110 hasRelatedWork W1964831661 @default.
• W2074316110 hasRelatedWork W1988885444 @default.
• W2074316110 hasRelatedWork W1997419347 @default.
• W2074316110 hasRelatedWork W2031289501 @default.
• W2074316110 hasRelatedWork W2046600857 @default.
• W2074316110 hasRelatedWork W2093476509 @default.
• W2074316110 hasRelatedWork W2141285552 @default.
• W2074316110 hasRelatedWork W2157441106 @default.
• W2074316110 hasRelatedWork W2515256355 @default.
• W2074316110 isParatext "false" @default.

• next