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- W2074317042 abstract "A high-pressure liquid chromatographic (HPLC) method for the analysis of bacitracing is described. The method uses as one-meter-long stainless-steel column packed with Bondapak C18/Corasil with a programmed convex gradient elution of decreasing polarity, from 5% methanol in pH 4.5 buffer to 40% methanol and 20% acetonitrile in pH 4.5 buffer, at a flow-rate of 0.90 ml/min. More than 22 components of bacitracin have been separated and analyzed in less than 40 min of chromatography. The number and proportions of the components contained in bacitracin powders varies greatly between manufacturers but remains relatively constant for each manufacturer. The antimicrobial activity of bacitracins B and C againstMicrococcus flavus, a standard test microorganism for the quantitation of bacitracin, is 87% and 30% of bacitracin A respectively. The relative standard deviation of the HPLC method is approximately 1%. Acute toxicity of bacitracin powder containing different proportions of the components and the effect of pharmaceutical manufacturing on sterile bacitracin are described." @default.
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- W2074317042 date "1974-01-01" @default.
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- W2074317042 title "Quantitative high-pressure liquid chromatographic analysis of bacitracin, a polypeptide antibiotic" @default.
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- W2074317042 doi "https://doi.org/10.1016/s0021-9673(00)90888-4" @default.
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