FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074317596> ?p ?o ?g. }

• W2074317596 endingPage "524" @default.
• W2074317596 startingPage "519" @default.
• W2074317596 abstract "Objective— Intracellular tumor necrosis factor receptor-associated factors (TRAFs) translocation to lipid rafts is a key element in CD40-induced signaling. The purpose of this study was to investigate the influence of anthocyanin on CD40-mediated proinflammatory events in human endothelial cells and the underlying possible molecular mechanism. Methods and Results— Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-κB (NF-κB) activation. TRAF-2 played pivotal role in CD40–NF-κB pathway as TRAF-2 small interference RNA (siRNA) diminished CD40-induced NF-κB activation and inflammation. TRAF-2 overexpression increased CD40-mediated NF-κB activation. Moreover, TRAF-2 almost totally recruited to lipid rafts after stimulation by CD40 ligand and depletion of cholesterol diminished CD40-mediated NF-κB activation. Exposure to anthocyanin not only interrupted TRAF-2 recruitment to lipid rafts but also decreased cholesterol content in Triton X-100 insoluble lipid rafts. However, anthocyanin did not influence the interaction between CD40 ligand and CD40 receptor. Conclusions— Our findings suggest that anthocyanin protects from CD40-induced proinflammatory signaling by preventing TRAF-2 translocation to lipid rafts through regulation of cholesterol distribution, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin." @default.
• W2074317596 created "2016-06-24" @default.
• W2074317596 creator A5021719486 @default.
• W2074317596 creator A5022956157 @default.
• W2074317596 creator A5034194667 @default.
• W2074317596 creator A5045856174 @default.
• W2074317596 creator A5064692375 @default.
• W2074317596 creator A5072315367 @default.
• W2074317596 creator A5077189352 @default.
• W2074317596 creator A5084386513 @default.
• W2074317596 creator A5084685500 @default.
• W2074317596 date "2007-03-01" @default.
• W2074317596 modified "2023-10-15" @default.
• W2074317596 title "Anthocyanin Prevents CD40-Activated Proinflammatory Signaling in Endothelial Cells by Regulating Cholesterol Distribution" @default.
• W2074317596 cites W1501518736 @default.
• W2074317596 cites W1678167583 @default.
• W2074317596 cites W1963761369 @default.
• W2074317596 cites W1964854662 @default.
• W2074317596 cites W1968985568 @default.
• W2074317596 cites W1994629334 @default.
• W2074317596 cites W2004680931 @default.
• W2074317596 cites W2018278847 @default.
• W2074317596 cites W2036399835 @default.
• W2074317596 cites W2036871785 @default.
• W2074317596 cites W2037181648 @default.
• W2074317596 cites W2043677945 @default.
• W2074317596 cites W2053215305 @default.
• W2074317596 cites W2061568467 @default.
• W2074317596 cites W2065886456 @default.
• W2074317596 cites W2070834812 @default.
• W2074317596 cites W2073003808 @default.
• W2074317596 cites W2074721095 @default.
• W2074317596 cites W2080494149 @default.
• W2074317596 cites W2094026225 @default.
• W2074317596 cites W2100359187 @default.
• W2074317596 cites W2111583062 @default.
• W2074317596 cites W2126708809 @default.
• W2074317596 cites W2137063799 @default.
• W2074317596 cites W2138319005 @default.
• W2074317596 cites W2141367941 @default.
• W2074317596 cites W2157825598 @default.
• W2074317596 cites W2166470267 @default.
• W2074317596 cites W2167259834 @default.
• W2074317596 doi "https://doi.org/10.1161/01.atv.0000254672.04573.2d" @default.
• W2074317596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17158355" @default.
• W2074317596 hasPublicationYear "2007" @default.
• W2074317596 type Work @default.
• W2074317596 sameAs 2074317596 @default.
• W2074317596 citedByCount "85" @default.
• W2074317596 countsByYear W20743175962012 @default.
• W2074317596 countsByYear W20743175962013 @default.
• W2074317596 countsByYear W20743175962014 @default.
• W2074317596 countsByYear W20743175962015 @default.
• W2074317596 countsByYear W20743175962016 @default.
• W2074317596 countsByYear W20743175962017 @default.
• W2074317596 countsByYear W20743175962018 @default.
• W2074317596 countsByYear W20743175962019 @default.
• W2074317596 countsByYear W20743175962020 @default.
• W2074317596 countsByYear W20743175962021 @default.
• W2074317596 countsByYear W20743175962022 @default.
• W2074317596 countsByYear W20743175962023 @default.
• W2074317596 crossrefType "journal-article" @default.
• W2074317596 hasAuthorship W2074317596A5021719486 @default.
• W2074317596 hasAuthorship W2074317596A5022956157 @default.
• W2074317596 hasAuthorship W2074317596A5034194667 @default.
• W2074317596 hasAuthorship W2074317596A5045856174 @default.
• W2074317596 hasAuthorship W2074317596A5064692375 @default.
• W2074317596 hasAuthorship W2074317596A5072315367 @default.
• W2074317596 hasAuthorship W2074317596A5077189352 @default.
• W2074317596 hasAuthorship W2074317596A5084386513 @default.
• W2074317596 hasAuthorship W2074317596A5084685500 @default.
• W2074317596 hasBestOaLocation W20743175961 @default.
• W2074317596 hasConcept C134018914 @default.
• W2074317596 hasConcept C154317977 @default.
• W2074317596 hasConcept C164027704 @default.
• W2074317596 hasConcept C17991360 @default.
• W2074317596 hasConcept C185592680 @default.
• W2074317596 hasConcept C202751555 @default.
• W2074317596 hasConcept C203014093 @default.
• W2074317596 hasConcept C2776914184 @default.
• W2074317596 hasConcept C2781184567 @default.
• W2074317596 hasConcept C39347974 @default.
• W2074317596 hasConcept C55493867 @default.
• W2074317596 hasConcept C62478195 @default.
• W2074317596 hasConcept C79266657 @default.
• W2074317596 hasConcept C86803240 @default.
• W2074317596 hasConcept C95444343 @default.
• W2074317596 hasConceptScore W2074317596C134018914 @default.
• W2074317596 hasConceptScore W2074317596C154317977 @default.
• W2074317596 hasConceptScore W2074317596C164027704 @default.
• W2074317596 hasConceptScore W2074317596C17991360 @default.
• W2074317596 hasConceptScore W2074317596C185592680 @default.
• W2074317596 hasConceptScore W2074317596C202751555 @default.
• W2074317596 hasConceptScore W2074317596C203014093 @default.
• W2074317596 hasConceptScore W2074317596C2776914184 @default.
• W2074317596 hasConceptScore W2074317596C2781184567 @default.
• W2074317596 hasConceptScore W2074317596C39347974 @default.
• W2074317596 hasConceptScore W2074317596C55493867 @default.

• next