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- W2074318470 abstract "1. 5-Hexyne-1,4-diamine (RMI 71696), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17) in vitro, causes a rapid, long-lasting, dose-dependent decrease of ornithine decarboxylase activity in prostate and to a lesser extent in thymus and testis of rats when injected intraperitoneally. 2. 5-Hexyne-1,4-diamine activates S-adenosylmethionine decarboxylase (EC 4.1.1.50) in vitro, analogously to putrescine. 3. Three doses of 100 mg/kg 5-hexyne-1, 4-diamine given to rats during a 24 hr period markedly decrease putrescine concentrations in prostate, thymus and testis and spermidine concentrations in prostate." @default.
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- W2074318470 date "1979-03-01" @default.
- W2074318470 modified "2023-10-18" @default.
- W2074318470 title "Decrease of polyamine levels in rat tissues by 5-hexyne-1,4-diamine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase" @default.
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- W2074318470 doi "https://doi.org/10.1016/0006-2952(79)90146-1" @default.
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