FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074328478> ?p ?o ?g. }

• W2074328478 endingPage "2919" @default.
• W2074328478 startingPage "2909" @default.
• W2074328478 abstract "Polychlorinated biphenyls (PCB) are industrial chemicals linked to developmental deficits that may be caused in part by disrupting thyroid hormone (TH) action by either reducing serum TH or interacting directly with the TH receptor (TR). Individual PCB congeners can activate the TR in vitro when the metabolic enzyme cytochrome P4501A1 (CYP1A1) is induced, suggesting that specific PCB metabolites act as TR agonists. To test this hypothesis in vivo, we compared two combinations of PCB congeners that either activate the TR (PCB 105 and 118) or not (PCB 138 and 153) in the presence or absence of a PCB congener (PCB 126) that induces CYP1A1 in vitro. Aroclor 1254 was used as a positive control, and a group treated with propylthiouracil was included to characterize the effects of low serum TH. We monitored the effects on TH signaling in several peripheral tissues by measuring the mRNA expression of well-known TH-response genes in these tissues. Aroclor 1254 and its component PCB 105/118/126 reduced total T(4) to the same extent as that of propylthiouracil but increased the expression of some TH target genes in liver. This effect was strongly correlated with CYP1A1 expression supporting the hypothesis that metabolism is necessary. Effects were gene and tissue specific, indicating that tissue-specific metabolism is an important component of PCB disruption of TH action and that PCB metabolites interact in complex ways with the TR. These are essential mechanisms to consider when evaluating the health risks of contaminant exposures, for both PCB and other polycyclic compounds known to interact with nuclear hormone receptors." @default.
• W2074328478 created "2016-06-24" @default.
• W2074328478 creator A5060791449 @default.
• W2074328478 creator A5066964688 @default.
• W2074328478 creator A5067857125 @default.
• W2074328478 creator A5074465011 @default.
• W2074328478 creator A5077633544 @default.
• W2074328478 date "2011-05-03" @default.
• W2074328478 modified "2023-10-10" @default.
• W2074328478 title "Individual Polychlorinated Biphenyl (PCB) Congeners Produce Tissue- and Gene-Specific Effects on Thyroid Hormone Signaling during Development" @default.
• W2074328478 cites W1532225933 @default.
• W2074328478 cites W1580842488 @default.
• W2074328478 cites W183628727 @default.
• W2074328478 cites W1968001856 @default.
• W2074328478 cites W1969487024 @default.
• W2074328478 cites W1971159204 @default.
• W2074328478 cites W1977674519 @default.
• W2074328478 cites W1981426689 @default.
• W2074328478 cites W1987255177 @default.
• W2074328478 cites W2005997880 @default.
• W2074328478 cites W2020260652 @default.
• W2074328478 cites W2022024669 @default.
• W2074328478 cites W2029981894 @default.
• W2074328478 cites W2041680723 @default.
• W2074328478 cites W2042268520 @default.
• W2074328478 cites W2043012281 @default.
• W2074328478 cites W2045898047 @default.
• W2074328478 cites W2049178128 @default.
• W2074328478 cites W2049819085 @default.
• W2074328478 cites W2053996154 @default.
• W2074328478 cites W2054354695 @default.
• W2074328478 cites W2063319145 @default.
• W2074328478 cites W2065346737 @default.
• W2074328478 cites W2071759715 @default.
• W2074328478 cites W2074735643 @default.
• W2074328478 cites W2078495475 @default.
• W2074328478 cites W2086257736 @default.
• W2074328478 cites W2087333553 @default.
• W2074328478 cites W2088704309 @default.
• W2074328478 cites W2089126666 @default.
• W2074328478 cites W2090221125 @default.
• W2074328478 cites W2091720000 @default.
• W2074328478 cites W2092214048 @default.
• W2074328478 cites W2094784421 @default.
• W2074328478 cites W2094805038 @default.
• W2074328478 cites W2106883177 @default.
• W2074328478 cites W2108244474 @default.
• W2074328478 cites W2120454188 @default.
• W2074328478 cites W2123625750 @default.
• W2074328478 cites W2154273881 @default.
• W2074328478 cites W2160240007 @default.
• W2074328478 cites W2162966206 @default.
• W2074328478 cites W2164762313 @default.
• W2074328478 cites W2165505426 @default.
• W2074328478 cites W2171987528 @default.
• W2074328478 doi "https://doi.org/10.1210/en.2010-1490" @default.
• W2074328478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3115602" @default.
• W2074328478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21540284" @default.
• W2074328478 hasPublicationYear "2011" @default.
• W2074328478 type Work @default.
• W2074328478 sameAs 2074328478 @default.
• W2074328478 citedByCount "81" @default.
• W2074328478 countsByYear W20743284782012 @default.
• W2074328478 countsByYear W20743284782013 @default.
• W2074328478 countsByYear W20743284782014 @default.
• W2074328478 countsByYear W20743284782015 @default.
• W2074328478 countsByYear W20743284782016 @default.
• W2074328478 countsByYear W20743284782017 @default.
• W2074328478 countsByYear W20743284782018 @default.
• W2074328478 countsByYear W20743284782019 @default.
• W2074328478 countsByYear W20743284782020 @default.
• W2074328478 countsByYear W20743284782021 @default.
• W2074328478 countsByYear W20743284782022 @default.
• W2074328478 countsByYear W20743284782023 @default.
• W2074328478 crossrefType "journal-article" @default.
• W2074328478 hasAuthorship W2074328478A5060791449 @default.
• W2074328478 hasAuthorship W2074328478A5066964688 @default.
• W2074328478 hasAuthorship W2074328478A5067857125 @default.
• W2074328478 hasAuthorship W2074328478A5074465011 @default.
• W2074328478 hasAuthorship W2074328478A5077633544 @default.
• W2074328478 hasBestOaLocation W20743284781 @default.
• W2074328478 hasConcept C104317684 @default.
• W2074328478 hasConcept C107872376 @default.
• W2074328478 hasConcept C109115496 @default.
• W2074328478 hasConcept C126322002 @default.
• W2074328478 hasConcept C134018914 @default.
• W2074328478 hasConcept C150194340 @default.
• W2074328478 hasConcept C170493617 @default.
• W2074328478 hasConcept C185592680 @default.
• W2074328478 hasConcept C202751555 @default.
• W2074328478 hasConcept C207001950 @default.
• W2074328478 hasConcept C2775960720 @default.
• W2074328478 hasConcept C2776365360 @default.
• W2074328478 hasConcept C2779357283 @default.
• W2074328478 hasConcept C526171541 @default.
• W2074328478 hasConcept C526584372 @default.
• W2074328478 hasConcept C54355233 @default.
• W2074328478 hasConcept C55493867 @default.

• next