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- W2074329123 abstract "The objectives of the present study were to identify the expression of a key immunological mediator of maternal immunity that is produced during sperm capacitation and to determine the relationship between its expression in sperm and its potential predictive value of successful pregnancy. A prospective controlled study. Sperm was induced for capacitation with Krebs-Ringer solution containing calcium and BSA or in normal saline. The sperm was assessed for routine markers and for the expression of a2V-ATPase (a2 isoform of vacuolar ATPase). Assessments were made by confocal microscopy and PCR. Immunolocalization to evaluate a2V protein expression, real-time PCR to evaluate gene expression of a2V and different cytokines, sandwich ELISA to evaluate the secretion of a2NTD, which is the secreted portion of a2V. The capacitation of sperm induced a2V transcription and up-regulated a2V protein expression. The expression of a2V was only detected in the appropriate capacitation buffer. No transcription or translation products were detected in sperm incubated in normal saline or PBS. Minimal expression of a2V was measured in Krebs-Ringer buffer without calcium or BSA. Capacitated sperm released a2NTD which can induce IL-1β, TNFα and MCP-1 (Monocyte chemotactic protein 1) expression. The results are compared between fertile couples and those being seen for treatment for recurrent pregnancy loss. We have previously reported that sperm capacitation induces the expression of the immune regulatory molecule a2V, which in turn causes the induction of inflammatory cytokines in the uterus. Capacitated sperm initiates the immunity of pregnancy by inducing a2V that in turn induces inflammatory cytokine expression during onset of pregnancy. We demonstrate that the maternal-fetal immune dialogue begins in the male with the capacitation of sperm and could be an immune predictor of fertility in women." @default.
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- W2074329123 date "2011-09-01" @default.
- W2074329123 modified "2023-09-26" @default.
- W2074329123 title "In pregnancy: active maternal immunity is induced by capacitated sperm" @default.
- W2074329123 doi "https://doi.org/10.1016/j.fertnstert.2011.07.369" @default.
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