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• W2074332565 abstract "ObjectiveIn vivo studies of antimicrobial PDT in animal models of oral candidosis are scarce and the association of porphyrin and LED light has not been evaluated for in vivo photoinactivation of Candida. In this study the effectiveness of photodynamic therapy (PDT) on the inactivation of Candida albicans in vivo was evaluated.Study designSeventy-one 6-week-old female Swiss mice were immunosuppressed, provided tetracycline to their drinking water, then orally swabbed with a suspension of C. albicans (107 CFU/mL). Four days after oral inoculation, PDT was performed on the dorsum of the tongue after topical administration of Photogem at 400, 500, or 1000 mg/L and followed 30 minutes later by illumination with LED light (305 J/cm2) at 455 or 630 nm (n = 5 each). After swabbing to recover yeast from the tongue, the number of surviving yeast cells was determined (CFU/mL) and analyzed by ANOVA and Holm-Sidak tests (P < .05). Animals were humanely killed, and the tongues surgically removed and processed for histological evaluation of presence of yeast and inflammatory reaction.ResultsPDT resulted in a significant reduction in C. albicans recovered from the tongue (P < .001) when compared with mice from the positive control group. There was no difference between the concentrations of Photogem and LED light wavelengths used. Histological evaluation of the tongue revealed that PDT causes no significant adverse effects to the local mucosa.ConclusionPDT promoted significant reduction in the viability of C. albicans biofilm without harming the tongue tissue. In vivo studies of antimicrobial PDT in animal models of oral candidosis are scarce and the association of porphyrin and LED light has not been evaluated for in vivo photoinactivation of Candida. In this study the effectiveness of photodynamic therapy (PDT) on the inactivation of Candida albicans in vivo was evaluated. Seventy-one 6-week-old female Swiss mice were immunosuppressed, provided tetracycline to their drinking water, then orally swabbed with a suspension of C. albicans (107 CFU/mL). Four days after oral inoculation, PDT was performed on the dorsum of the tongue after topical administration of Photogem at 400, 500, or 1000 mg/L and followed 30 minutes later by illumination with LED light (305 J/cm2) at 455 or 630 nm (n = 5 each). After swabbing to recover yeast from the tongue, the number of surviving yeast cells was determined (CFU/mL) and analyzed by ANOVA and Holm-Sidak tests (P < .05). Animals were humanely killed, and the tongues surgically removed and processed for histological evaluation of presence of yeast and inflammatory reaction. PDT resulted in a significant reduction in C. albicans recovered from the tongue (P < .001) when compared with mice from the positive control group. There was no difference between the concentrations of Photogem and LED light wavelengths used. Histological evaluation of the tongue revealed that PDT causes no significant adverse effects to the local mucosa. PDT promoted significant reduction in the viability of C. albicans biofilm without harming the tongue tissue." @default.
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• W2074332565 date "2010-03-01" @default.
• W2074332565 modified "2023-10-18" @default.
• W2074332565 title "Susceptibility of Candida albicans to photodynamic therapy in a murine model of oral candidosis" @default.
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• W2074332565 cites W1964315121 @default.
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• W2074332565 cites W1973697574 @default.
• W2074332565 cites W1979754681 @default.
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• W2074332565 cites W1990959361 @default.
• W2074332565 cites W1998301365 @default.
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• W2074332565 cites W2007451007 @default.
• W2074332565 cites W2011917369 @default.
• W2074332565 cites W2019098068 @default.
• W2074332565 cites W2020904791 @default.
• W2074332565 cites W2031686290 @default.
• W2074332565 cites W2034277023 @default.
• W2074332565 cites W2042974423 @default.
• W2074332565 cites W2045874111 @default.
• W2074332565 cites W2046120865 @default.
• W2074332565 cites W2058709977 @default.
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• W2074332565 cites W2064841056 @default.
• W2074332565 cites W2064947404 @default.
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• W2074332565 cites W2072561567 @default.
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• W2074332565 cites W2089373105 @default.
• W2074332565 cites W2090824963 @default.
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• W2074332565 cites W2134433520 @default.
• W2074332565 cites W2135038558 @default.
• W2074332565 cites W2139759848 @default.
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• W2074332565 doi "https://doi.org/10.1016/j.tripleo.2009.10.006" @default.
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