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• W2074342234 endingPage "2320" @default.
• W2074342234 startingPage "2313" @default.
• W2074342234 abstract "Cis-elements(−933 to −641) upstream of the human M creatine kinase gene cap site contain an enhancer that confers developmental and tissue-specific expression to the chioramphenicol acetyltransferase gene in C2C12 myogenic cells transfected in culture. Division of the enhancer at −770 into a 5′ fragment that includes the MyoD binding sites (−933 to −770) and a 3′ fragment that includes the MEF-2 binding site (−770 to −641) resulted in two subfragments that showed minimal activity but in combination interacted in a position- and orientation-independent fashion to enhance activity of the SV4O promoter in transient transfection experiments. A 5′ enhancer construct (−877 to −832) including only one (the low affinity) MyoD binding site was active when present in multiple copies. In contrast, a 3′ enhancer construct (−749 to −732) including the MEF-2 binding site was inactive even when present in multiple copies. However, if the 5′ construct was extended to include the high-affinity MyoD binding site (−877 to −803) the 5′ and 3′ constructs interacted in a position- and orientation-independent fashion to activate the SV4O promoter. Thus, the human M creatine kinase enhancer comprises multiple functional interacting domains." @default.
• W2074342234 created "2016-06-24" @default.
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• W2074342234 date "1992-01-01" @default.
• W2074342234 modified "2023-09-27" @default.
• W2074342234 title "The human M creatine kinase gene enhancer contains multiple functional interacting domains" @default.
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• W2074342234 doi "https://doi.org/10.1093/nar/20.9.2313" @default.
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