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• W2074347579 startingPage "324" @default.
• W2074347579 abstract "Previous research suggests that testosterone (T) plays a key role in shaping competitive and aggressive behavior in humans, possibly by modulating threat-related neural circuitry. However, this research has been limited by the use of T augmentation that fails to account for baseline differences and has been conducted exclusively in women. Thus, the extent to which normal physiologic concentrations of T affect threat-related brain function in men remains unknown.In the current study, we use a novel two-step pharmacologic challenge protocol to overcome these limitations and to evaluate causal modulation of threat- and aggression-related neural circuits by T in healthy young men (n = 16). First, we controlled for baseline differences in T through administration of a gonadotropin releasing hormone antagonist. Once a common baseline was established across participants, we then administered T to within the normal physiologic range. During this second step of the protocol we acquired functional neuroimaging data to examine the impact of T augmentation on neural circuitry supporting threat and aggression.Gonadotropin releasing hormone antagonism successfully reduced circulating concentrations of T and brought subjects to a common baseline. Administration of T rapidly increased circulating T concentrations and was associated with heightened reactivity of the amygdala, hypothalamus, and periaqueductal grey to angry facial expressions.These findings provide novel causal evidence that T rapidly potentiates the response of neural circuits mediating threat processing and aggressive behavior in men." @default.
• W2074347579 created "2016-06-24" @default.
• W2074347579 creator A5006780906 @default.
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• W2074347579 creator A5062228109 @default.
• W2074347579 creator A5077759235 @default.
• W2074347579 date "2014-08-01" @default.
• W2074347579 modified "2023-10-16" @default.
• W2074347579 title "Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge Paradigm" @default.
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• W2074347579 doi "https://doi.org/10.1016/j.biopsych.2014.01.016" @default.
• W2074347579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24576686" @default.
• W2074347579 hasPublicationYear "2014" @default.
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