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• W2074349610 abstract "area is the possibility that groups of cytokines st imulate specific pat terns of expression of receptors and that this pa t te rn is responsible for behavior of the cell and can be diagnosed by MAb. Third, the possibility of having clinically relevant antagonists is real with the development of powerful blocking M A b and, perhaps more important , of analogues of growth factors that act as antagonists by specifically binding one of the chains of the receptors for these factors (Tables V and VI). Al though each of these reagents may have significant drawbacks in clinical use (the M A b is mur ine and the antagonist must be used in excess over ligand of approximately 100 times), each points the way for the specific design of smaller molecules that may be more po ten t and more easily administered. Finally, the effect of cyclosporine on cells o ther than T lymphocytes also points the way for the inhibition of t ranscript ion of cytokine genes in non-T cells. The particularly attractive possibility is that there exist several pathways of activation only some of the activation pathways are sensitive to cyclosporine. If this were to be the case, it may be possible to target activation pathways specific for allergy." @default.
• W2074349610 created "2016-06-24" @default.
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• W2074349610 date "1994-12-01" @default.
• W2074349610 modified "2023-09-30" @default.
• W2074349610 title "The clinical relevance of basophil releasability" @default.
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• W2074349610 doi "https://doi.org/10.1016/0091-6749(94)90345-x" @default.
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