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• W2074354584 abstract "Elongated, more highly polyunsaturated derivatives of linoleic acid (18:2ω-6) and linolenic acid (18:3ω-3) accumulate in brain, but their sites of synthesis and mechanism of entry are not well characterized. To investigate the role of the blood-brain barrier in this process, cultured murine cere-bromicrovascular endothelia were incubated with [1-14C]18: 2ω-6 or [1-14C]18:3ω-3 and their elongation/desaturation products determined. The major metabolite of 18:2ω-6 was 20:4ω-6, whereas the primary product from 18:3ω-3 was 20: 5ω-3. Although these products were found primarily in cell lipids, they were also released from the cells and gradually accumulated in the extracellular fluid. Eicosanoid production was observed from the 20:4ω-6 and 20:5ω-3 that were formed. No 22:5ω-6 or 22:6ω-3 fatty acids were detected, suggesting that these endothelial cells are not the site of the final desaturation step. Although the uptake of 18:3ω-3 and 18:2ω-6 was nearly identical, 18:3ω-3 was more extensively elongated and desaturated. Competition experiments demonstrated a preference for 18:3ω-3 by the elongation/desaturation pathway. These findings suggest that the blood-brain barrier can play an important role in the elongation and desaturation of ω-3 and ω-6 essential fatty acids during their transfer from the circulation into the brain." @default.
• W2074354584 created "2016-06-24" @default.
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• W2074354584 date "1990-08-01" @default.
• W2074354584 modified "2023-09-24" @default.
• W2074354584 title "Role of the Blood-Brain Barrier in the Formation of Long-Chain ?-3 and ?-6 Fatty Acids from Essential Fatty Acid Precursors" @default.
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• W2074354584 doi "https://doi.org/10.1111/j.1471-4159.1990.tb04150.x" @default.
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