FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074355634> ?p ?o ?g. }

• W2074355634 endingPage "61" @default.
• W2074355634 startingPage "46" @default.
• W2074355634 abstract "A novel endothelial cell apoptosis inducing metalloprotease (VLAIP) was found in the snake venom of Vipera lebetina. This metalloprotease is a heterodimeric glycoprotein with molecular mass of about 106 kDa. The protease hydrolyzes azocasein, fibrinogen and oxidized insulin B-chain. The enzyme readily hydrolyzes the Aα-chain and more slowly Bβ-chain of fibrinogen. VLAIP does not cleave fibrin. The complete amino acid sequences of the two different monomers of VLAIP are deduced from the nucleotide sequences of cDNAs encoding these proteins. The full-length cDNA sequences of the VLAIP-A and VLAIP-B encode open reading frames of 616 and 614 amino acids that include signal peptide, propeptide and mature metalloproteinase with disintegrin-like and cysteine-rich domains. VLAIP belongs to the metalloprotease/disintegrin family of reprolysins and has high identity with the proteins that induce apoptosis of endothelial cells. Treatment of HUVEC cells with VLAIP induces changes in the attachment of cells to the substrate and causes cell death. We demonstrated that VLAIP inhibits endothelial cell adhesion to extracellular matrix proteins: fibrinogen, fibronectin, vitronectin, collagen I, and collagen IV. The induction of apoptosis by VLAIP was shown by means of a typical DNA fragmentation pattern of apoptotic cells as well as by monitoring phosphatidylserine externalization using annexin V-FITC staining and flow cytometric analysis." @default.
• W2074355634 created "2016-06-24" @default.
• W2074355634 creator A5016252849 @default.
• W2074355634 creator A5025188410 @default.
• W2074355634 creator A5025972377 @default.
• W2074355634 creator A5026682216 @default.
• W2074355634 creator A5068158867 @default.
• W2074355634 creator A5075114848 @default.
• W2074355634 creator A5076012106 @default.
• W2074355634 creator A5077072222 @default.
• W2074355634 creator A5082336551 @default.
• W2074355634 creator A5084662156 @default.
• W2074355634 creator A5085022373 @default.
• W2074355634 creator A5091604892 @default.
• W2074355634 date "2005-07-01" @default.
• W2074355634 modified "2023-10-18" @default.
• W2074355634 title "A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis" @default.
• W2074355634 cites W1522825458 @default.
• W2074355634 cites W1645271899 @default.
• W2074355634 cites W1886264513 @default.
• W2074355634 cites W1890321828 @default.
• W2074355634 cites W1967670793 @default.
• W2074355634 cites W1970353663 @default.
• W2074355634 cites W1975391008 @default.
• W2074355634 cites W1976643373 @default.
• W2074355634 cites W1976707921 @default.
• W2074355634 cites W1981383840 @default.
• W2074355634 cites W1987834154 @default.
• W2074355634 cites W1990424781 @default.
• W2074355634 cites W1992252477 @default.
• W2074355634 cites W2024656593 @default.
• W2074355634 cites W2033585544 @default.
• W2074355634 cites W2042327663 @default.
• W2074355634 cites W2049197525 @default.
• W2074355634 cites W2054257117 @default.
• W2074355634 cites W2055580270 @default.
• W2074355634 cites W2061497413 @default.
• W2074355634 cites W2067336074 @default.
• W2074355634 cites W2071119185 @default.
• W2074355634 cites W2071320462 @default.
• W2074355634 cites W2074279395 @default.
• W2074355634 cites W2077237768 @default.
• W2074355634 cites W2082413036 @default.
• W2074355634 cites W2083519420 @default.
• W2074355634 cites W2084821293 @default.
• W2074355634 cites W2087094729 @default.
• W2074355634 cites W2088701084 @default.
• W2074355634 cites W2093966095 @default.
• W2074355634 cites W2100837269 @default.
• W2074355634 cites W2102818855 @default.
• W2074355634 cites W2113295527 @default.
• W2074355634 cites W2148187441 @default.
• W2074355634 cites W2157603347 @default.
• W2074355634 cites W2158714788 @default.
• W2074355634 cites W2168926228 @default.
• W2074355634 cites W2241022532 @default.
• W2074355634 cites W23530191 @default.
• W2074355634 cites W4232808932 @default.
• W2074355634 doi "https://doi.org/10.1016/j.toxicon.2005.03.008" @default.
• W2074355634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15922394" @default.
• W2074355634 hasPublicationYear "2005" @default.
• W2074355634 type Work @default.
• W2074355634 sameAs 2074355634 @default.
• W2074355634 citedByCount "70" @default.
• W2074355634 countsByYear W20743556342012 @default.
• W2074355634 countsByYear W20743556342013 @default.
• W2074355634 countsByYear W20743556342014 @default.
• W2074355634 countsByYear W20743556342015 @default.
• W2074355634 countsByYear W20743556342016 @default.
• W2074355634 countsByYear W20743556342017 @default.
• W2074355634 countsByYear W20743556342018 @default.
• W2074355634 countsByYear W20743556342019 @default.
• W2074355634 countsByYear W20743556342020 @default.
• W2074355634 countsByYear W20743556342021 @default.
• W2074355634 countsByYear W20743556342022 @default.
• W2074355634 countsByYear W20743556342023 @default.
• W2074355634 crossrefType "journal-article" @default.
• W2074355634 hasAuthorship W2074355634A5016252849 @default.
• W2074355634 hasAuthorship W2074355634A5025188410 @default.
• W2074355634 hasAuthorship W2074355634A5025972377 @default.
• W2074355634 hasAuthorship W2074355634A5026682216 @default.
• W2074355634 hasAuthorship W2074355634A5068158867 @default.
• W2074355634 hasAuthorship W2074355634A5075114848 @default.
• W2074355634 hasAuthorship W2074355634A5076012106 @default.
• W2074355634 hasAuthorship W2074355634A5077072222 @default.
• W2074355634 hasAuthorship W2074355634A5082336551 @default.
• W2074355634 hasAuthorship W2074355634A5084662156 @default.
• W2074355634 hasAuthorship W2074355634A5085022373 @default.
• W2074355634 hasAuthorship W2074355634A5091604892 @default.
• W2074355634 hasConcept C109523444 @default.
• W2074355634 hasConcept C153911025 @default.
• W2074355634 hasConcept C167814343 @default.
• W2074355634 hasConcept C185592680 @default.
• W2074355634 hasConcept C190283241 @default.
• W2074355634 hasConcept C2778259572 @default.
• W2074355634 hasConcept C55493867 @default.
• W2074355634 hasConcept C55728118 @default.
• W2074355634 hasConcept C86803240 @default.

• next