FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074355872> ?p ?o ?g. }

• W2074355872 endingPage "502" @default.
• W2074355872 startingPage "492" @default.
• W2074355872 abstract "Microsomal prostaglandin E(2) synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE(2). Early growth response factor-1 (Egr-1) is a key transcription factor in the regulation of mPGES-1, and its activity is negatively regulated by the corepressor NGF1-A-binding protein-1 (NAB1). We examined the effects of valproic acid (VA), a histone deacetylase inhibitor, on interleukin 1ß (IL-1ß)-induced mPGES-1 expression in human chondrocytes, and evaluated the roles of Egr-1 and NAB1 in these effects.Chondrocytes were stimulated with IL-1 in the absence or presence of VA, and the level of mPGES-1 protein and mRNA expression were evaluated using Western blotting and real-time reverse-transcription polymerase chain reaction (PCR), respectively. mPGES-1 promoter activity was analyzed in transient transfection experiments. Egr-1 and NAB1 recruitment to the mPGES-1 promoter was evaluated using chromatin immunoprecipitation assays. Small interfering RNA (siRNA) approaches were used to silence NAB1 expression.VA dose-dependently suppressed IL-1-induced mPGES-1 protein and mRNA expression as well as its promoter activation. Treatment with VA did not alter IL-1-induced Egr-1 expression, or its recruitment to the mPGES-1 promoter, but prevented its transcriptional activity. The suppressive effect of VA requires de novo protein synthesis. VA induced the expression of NAB1, and its recruitment to the mPGES-1 promoter, suggesting that NAB1 may mediate the suppressive effect of VA. Indeed, NAB1 silencing with siRNA blocked VA-mediated suppression of IL-1-induced mPGES-1 expression.VA inhibited IL-1-induced mPGES-1 expression in chondrocytes. The suppressive effect of VA was not due to reduced expression or recruitment of Egr-1 to the mPGES-1 promoter and involved upregulation of NAB1." @default.
• W2074355872 created "2016-06-24" @default.
• W2074355872 creator A5026711692 @default.
• W2074355872 creator A5032321171 @default.
• W2074355872 creator A5033883809 @default.
• W2074355872 creator A5051212787 @default.
• W2074355872 creator A5053214598 @default.
• W2074355872 creator A5066040148 @default.
• W2074355872 creator A5074881383 @default.
• W2074355872 creator A5083125761 @default.
• W2074355872 creator A5088257611 @default.
• W2074355872 date "2011-01-15" @default.
• W2074355872 modified "2023-09-25" @default.
• W2074355872 title "Valproic Acid Suppresses Interleukin-1ß-induced Microsomal Prostaglandin E₂Synthase-1 Expression in Chondrocytes Through Upregulation of NAB1" @default.
• W2074355872 cites W1687504009 @default.
• W2074355872 cites W1695507732 @default.
• W2074355872 cites W1967641836 @default.
• W2074355872 cites W1968317137 @default.
• W2074355872 cites W1968671346 @default.
• W2074355872 cites W1975692560 @default.
• W2074355872 cites W1998188269 @default.
• W2074355872 cites W1999976727 @default.
• W2074355872 cites W2004065216 @default.
• W2074355872 cites W2006345574 @default.
• W2074355872 cites W2008368193 @default.
• W2074355872 cites W2010231609 @default.
• W2074355872 cites W2015257413 @default.
• W2074355872 cites W2028438001 @default.
• W2074355872 cites W2033361258 @default.
• W2074355872 cites W2036673566 @default.
• W2074355872 cites W2038171112 @default.
• W2074355872 cites W2039098916 @default.
• W2074355872 cites W2046934643 @default.
• W2074355872 cites W2052815426 @default.
• W2074355872 cites W2058097591 @default.
• W2074355872 cites W2058273658 @default.
• W2074355872 cites W2060021617 @default.
• W2074355872 cites W2063347675 @default.
• W2074355872 cites W2063355095 @default.
• W2074355872 cites W2068775998 @default.
• W2074355872 cites W2072769860 @default.
• W2074355872 cites W2073978750 @default.
• W2074355872 cites W2075982837 @default.
• W2074355872 cites W2077641423 @default.
• W2074355872 cites W2079965786 @default.
• W2074355872 cites W2088665109 @default.
• W2074355872 cites W2111199059 @default.
• W2074355872 cites W2117540633 @default.
• W2074355872 cites W2123995229 @default.
• W2074355872 cites W2125376440 @default.
• W2074355872 cites W2133633020 @default.
• W2074355872 cites W2134407449 @default.
• W2074355872 cites W2135047663 @default.
• W2074355872 cites W2143994006 @default.
• W2074355872 cites W2144153160 @default.
• W2074355872 cites W2147330842 @default.
• W2074355872 cites W2155913937 @default.
• W2074355872 cites W2167029659 @default.
• W2074355872 cites W2167415368 @default.
• W2074355872 cites W2168680690 @default.
• W2074355872 cites W2170812501 @default.
• W2074355872 cites W31775548 @default.
• W2074355872 cites W4244530419 @default.
• W2074355872 doi "https://doi.org/10.3899/jrheum.100907" @default.
• W2074355872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21239760" @default.
• W2074355872 hasPublicationYear "2011" @default.
• W2074355872 type Work @default.
• W2074355872 sameAs 2074355872 @default.
• W2074355872 citedByCount "12" @default.
• W2074355872 countsByYear W20743558722012 @default.
• W2074355872 countsByYear W20743558722013 @default.
• W2074355872 countsByYear W20743558722014 @default.
• W2074355872 countsByYear W20743558722015 @default.
• W2074355872 countsByYear W20743558722019 @default.
• W2074355872 countsByYear W20743558722020 @default.
• W2074355872 countsByYear W20743558722021 @default.
• W2074355872 countsByYear W20743558722022 @default.
• W2074355872 crossrefType "journal-article" @default.
• W2074355872 hasAuthorship W2074355872A5026711692 @default.
• W2074355872 hasAuthorship W2074355872A5032321171 @default.
• W2074355872 hasAuthorship W2074355872A5033883809 @default.
• W2074355872 hasAuthorship W2074355872A5051212787 @default.
• W2074355872 hasAuthorship W2074355872A5053214598 @default.
• W2074355872 hasAuthorship W2074355872A5066040148 @default.
• W2074355872 hasAuthorship W2074355872A5074881383 @default.
• W2074355872 hasAuthorship W2074355872A5083125761 @default.
• W2074355872 hasAuthorship W2074355872A5088257611 @default.
• W2074355872 hasBestOaLocation W20743558721 @default.
• W2074355872 hasConcept C101762097 @default.
• W2074355872 hasConcept C104317684 @default.
• W2074355872 hasConcept C105580179 @default.
• W2074355872 hasConcept C119056186 @default.
• W2074355872 hasConcept C127561419 @default.
• W2074355872 hasConcept C134320426 @default.
• W2074355872 hasConcept C138885662 @default.
• W2074355872 hasConcept C146777309 @default.
• W2074355872 hasConcept C150194340 @default.
• W2074355872 hasConcept C153911025 @default.

• next