FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074390842> ?p ?o ?g. }

• W2074390842 endingPage "334" @default.
• W2074390842 startingPage "325" @default.
• W2074390842 abstract "HPC-1/syntaxin 1A is a member of the syntaxin family, and functions at the plasma membrane during membrane fusion as the target-soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (t-SNARE). We identified the membrane-anchoring region of HPC-1/syntaxin 1A, and examined its role in anchoring of a protein to the plasma membrane. A series of mutants was created from a cysteine-less mutant of HPC-1/syntaxin 1A by substitution of each residue at the C-terminus with cysteine. The accessibility of the thiol-groups in each mutant was analyzed in vivo. The cysteine (C145) within the N-terminal cytosolic segment was labeled, but not that at C271 or C272, or any of those introduced at the C-terminus. The addition of additional residues to the C-terminal tail of HPC-1/syntaxin 1A allowed labeling by thiol-specific reagents. A monoclonal antibody directed against the C-terminal tail peptide did not react with the protein located at the plasma membrane. In addition, subcellular fractionation and immunocytochemical analyses with various transmembrane mutants showed that the C-terminal tail comprising eight amino acids is essential for anchoring of HPC-1/syntaxin 1A to the plasma membrane. These results indicate that the C-terminal membrane-anchoring region, which comprises 23 amino acids, does not traverse the lipid-bilayer and that the C-terminal tail is essential for anchoring of HPC-1/syntaxin 1A to the plasma membrane." @default.
• W2074390842 created "2016-06-24" @default.
• W2074390842 creator A5007966580 @default.
• W2074390842 creator A5032993119 @default.
• W2074390842 creator A5086200068 @default.
• W2074390842 date "2003-03-01" @default.
• W2074390842 modified "2023-10-18" @default.
• W2074390842 title "Identification of the Carboxyl-Terminal Membrane-Anchoring Region of HPC-1/Syntaxin 1A with the Substituted-Cysteine-Accessibility Method and Monoclonal Antibodies" @default.
• W2074390842 cites W1481032119 @default.
• W2074390842 cites W1574626580 @default.
• W2074390842 cites W1600122389 @default.
• W2074390842 cites W1822252127 @default.
• W2074390842 cites W1966364658 @default.
• W2074390842 cites W1971016259 @default.
• W2074390842 cites W1975304761 @default.
• W2074390842 cites W1975427295 @default.
• W2074390842 cites W1977356588 @default.
• W2074390842 cites W1984394526 @default.
• W2074390842 cites W1986284865 @default.
• W2074390842 cites W1993069705 @default.
• W2074390842 cites W1998987638 @default.
• W2074390842 cites W1999213641 @default.
• W2074390842 cites W2002095327 @default.
• W2074390842 cites W2002669633 @default.
• W2074390842 cites W2014840904 @default.
• W2074390842 cites W2019113077 @default.
• W2074390842 cites W2027407556 @default.
• W2074390842 cites W2032636718 @default.
• W2074390842 cites W2041946718 @default.
• W2074390842 cites W2042968365 @default.
• W2074390842 cites W2049550397 @default.
• W2074390842 cites W2051103934 @default.
• W2074390842 cites W2061491052 @default.
• W2074390842 cites W2067827045 @default.
• W2074390842 cites W2082752892 @default.
• W2074390842 cites W2090495738 @default.
• W2074390842 cites W2100837269 @default.
• W2074390842 cites W2114083522 @default.
• W2074390842 cites W2117919289 @default.
• W2074390842 cites W2120684043 @default.
• W2074390842 cites W2142125386 @default.
• W2074390842 cites W2150383975 @default.
• W2074390842 cites W2152770371 @default.
• W2074390842 cites W2168034470 @default.
• W2074390842 cites W2246981588 @default.
• W2074390842 cites W7725224 @default.
• W2074390842 doi "https://doi.org/10.1093/jb/mvg044" @default.
• W2074390842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12761168" @default.
• W2074390842 hasPublicationYear "2003" @default.
• W2074390842 type Work @default.
• W2074390842 sameAs 2074390842 @default.
• W2074390842 citedByCount "18" @default.
• W2074390842 countsByYear W20743908422013 @default.
• W2074390842 countsByYear W20743908422015 @default.
• W2074390842 countsByYear W20743908422022 @default.
• W2074390842 crossrefType "journal-article" @default.
• W2074390842 hasAuthorship W2074390842A5007966580 @default.
• W2074390842 hasAuthorship W2074390842A5032993119 @default.
• W2074390842 hasAuthorship W2074390842A5086200068 @default.
• W2074390842 hasConcept C118892022 @default.
• W2074390842 hasConcept C144647389 @default.
• W2074390842 hasConcept C170493617 @default.
• W2074390842 hasConcept C181199279 @default.
• W2074390842 hasConcept C185592680 @default.
• W2074390842 hasConcept C24530287 @default.
• W2074390842 hasConcept C2778256703 @default.
• W2074390842 hasConcept C2779201268 @default.
• W2074390842 hasConcept C41625074 @default.
• W2074390842 hasConcept C515207424 @default.
• W2074390842 hasConcept C55493867 @default.
• W2074390842 hasConcept C79061702 @default.
• W2074390842 hasConcept C86803240 @default.
• W2074390842 hasConcept C95444343 @default.
• W2074390842 hasConceptScore W2074390842C118892022 @default.
• W2074390842 hasConceptScore W2074390842C144647389 @default.
• W2074390842 hasConceptScore W2074390842C170493617 @default.
• W2074390842 hasConceptScore W2074390842C181199279 @default.
• W2074390842 hasConceptScore W2074390842C185592680 @default.
• W2074390842 hasConceptScore W2074390842C24530287 @default.
• W2074390842 hasConceptScore W2074390842C2778256703 @default.
• W2074390842 hasConceptScore W2074390842C2779201268 @default.
• W2074390842 hasConceptScore W2074390842C41625074 @default.
• W2074390842 hasConceptScore W2074390842C515207424 @default.
• W2074390842 hasConceptScore W2074390842C55493867 @default.
• W2074390842 hasConceptScore W2074390842C79061702 @default.
• W2074390842 hasConceptScore W2074390842C86803240 @default.
• W2074390842 hasConceptScore W2074390842C95444343 @default.
• W2074390842 hasIssue "3" @default.
• W2074390842 hasLocation W20743908421 @default.
• W2074390842 hasLocation W20743908422 @default.
• W2074390842 hasOpenAccess W2074390842 @default.
• W2074390842 hasPrimaryLocation W20743908421 @default.
• W2074390842 hasRelatedWork W1872820026 @default.
• W2074390842 hasRelatedWork W1964607696 @default.
• W2074390842 hasRelatedWork W1974240269 @default.
• W2074390842 hasRelatedWork W1992657771 @default.
• W2074390842 hasRelatedWork W2036123216 @default.
• W2074390842 hasRelatedWork W2040208869 @default.

• next