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- W2074399282 abstract "Annals of the New York Academy of SciencesVolume 565, Issue 1 p. 222-226 Chemotherapy and Hemoglobin F Synthesis in Sickle Cell Diseasea GEORGE J. DOVER, GEORGE J. DOVER Departments of Pediatrics and Medicine Johns Hopkins University Medical School 720 Rutland Avenue 906 Traylor Building Baltimore, Maryland 21205Search for more papers by this authorSAMUEL CHARACHE, SAMUEL CHARACHE Departments of Pathology and Laboratory Medicine The Johns Hopkins Hospital 600 North Wolf Street B121D Meyer Building Baltimore, Maryland 21205Search for more papers by this author GEORGE J. DOVER, GEORGE J. DOVER Departments of Pediatrics and Medicine Johns Hopkins University Medical School 720 Rutland Avenue 906 Traylor Building Baltimore, Maryland 21205Search for more papers by this authorSAMUEL CHARACHE, SAMUEL CHARACHE Departments of Pathology and Laboratory Medicine The Johns Hopkins Hospital 600 North Wolf Street B121D Meyer Building Baltimore, Maryland 21205Search for more papers by this author First published: July 1989 https://doi.org/10.1111/j.1749-6632.1989.tb24170.xCitations: 5 a Supported by National Institutes of Health grants no. HJL-02799 and NHLB R01 28028-07, General Clinical Research Center grant no. RR35, Outpatient Research Center grant no. RR 00722, and a grant from the Central Maryland Committee on Sickle Cell Anemia, Inc. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES 1 Watson, J. 1948. The significance of the paucity of sickle cells in newborn Negro infants. Am. J. Med. Sci. 215: 419. 2 Herman, E. C., Jr & C. L. Conley. 1960. Hereditary persistence of fetal hemoglobin. A family study. Am. J. Med. 29: 9. 3 Singer, K. & L. Singer. 1953. Studies on abnormal hemoglobins. VIII. The gelling phenomenon of sickle-cell hemoglobin: its biologic and diagnostic significance. Blood 8: 1008. 4 Bertles, J. F., R. Rabinowitz & J. Dobler. 1970. Hemoglobin interaction: modification of solid phase composition in the sickling phenomenon. Science 169: 375. 5 Nagel, R. L., R. M. Bookchin, J. Johnson, D. Labie, H. Wajcman, W. A. Isaac-Sodeye, G. R. Honig, G. Schiliro, J. H. Crookston & K. Matsumoto. 1979. Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S. Proc. Nat. Acad. Sci. USA 76: 670. 6 Goldberg, M. A., M. A. Husson & H. F. Bunn. 1977. Participation of hemoglobins A and F in polymerization of sickle hemoglobin. J. Biol. Chem. 252: 3414. 7 Stamatoyannopoulos, G. & A. Nienhuis. 1983. Globin Gene Expression and Hemopoietic Differentiation. Alan R. Liss, Inc. New York , N.Y. 8 De Simone, J., P. Heller, L. Hall & D. Zwiers. 1982. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc. Nat. Acad. Sci. USA 79: 4428. 9 Ley, T. J., J. De Simone, N. P. Anagnou, G. H. Keller, R. K. Humphries, P. H. Turner, N. S. Young, P. Heller & A. W. Nienhuis. 1982. 5-Azacytidine selectively increases gamma-globulin synthesis in a patient with beta-plus thalassemia. N. Engl. J. Med. 307: 1469. 10 Ley, T. J., J. De Simone, C. T. Noguchi, P. H. Turner, A. N. Schechter, P. Heller & A. W. Nienhuis. 1983. 5-Azacytidine increases γ-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. Blood 62(2): 370– 380. 11 Charache, S., G. J. Dover, K. D. Smith & C. C. Talbot. 1983. Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with non-random hypo-methylation of DNA around the γ-δ-B globin gene complex. Proc. Nat. Acad. Sci. USA 80: 4842. 12 Dover, G. J., S. Charache, S. H. Boyer, G. Vogelsang & M. Mover. 1985. 5-Azacytidine increases Hb F production and reduces anemia in sickle cell disease: dose-response analysis of subcutaneous and oral dosage regimens. Blood 66: 527. 13 Letvin, N. L., D. C. Linch, P. Beardsley, K. W. McIntyre & D. G. Nathan. 1984. Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. N. Engl. J. Med. 310: 869. 14 Papayannopoulou, T., A. Torjealba-Deron, R. Veith, G. Knitter & E. Stamatoyannopoulou. 1984. Arabinosylcytosine induces fetal hemoglobins in baboons by perturbing erythroid cell differentiation kinetics. Science 224: 617– 619. 15 Letvin, N. L., D. L. Linch, T. P. Beardsley, K. W. McIntyre, B. Miller & D. G. Nathan. 1985. Influence of cell cycle specific agents on simian fetal hemoglobin synthesis. J. Clin. Invest. 75: 1999. 16 Platt, O. S., S. H. Orkin, G. Dover, G. P. Beardsley, B. Miller & D. G. Nathan. 1984. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J. Clin. Invest. 74: 652. 17 Veith, R., R. Galanello, T. Papayannopoulou & G. Stamatoyannopoulos. 1985. Stimulation of F-cell production in patients with sickle-cell anemia treated with cytara-bine or hydroxyurea. N. Engl. J. Med. 313: 1571. 18 Kaplan, M. E., K. Mack, J. D. Goldberg, P. B. Donovan, P. D. Berk & L. R. Wasserman. 1986. Long term management of polycythemia vera with hydroxyurea: a progress report. Semin. Hematol. 23: 167. 19 Dover, G. J., R. K. Humphries, J. G. Moore, T. J. Ley, N. S. Young, S. Charache & A. W. Nienhuis. 1986. Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production. Blood 67: 735. 20 Charache, S., G. J. Dover, M. A. Mover & J. W. Moore. 1987. Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood 69: 109– 116. 21 Sumoza, A. & R. S. Biscotti. 1986. Treatment of sickle cell anemia with hydroxyurea. Blood 68: 67a. 22 Alter, B. P. & H. S. Gilbert. 1985. The effect of hydroxyurea on hemoglobin F in patients with myeloproliferative syndromes. Blood 66: 373. 23 Veith, R., T. Papayannopoulou, S. Kurachi & G. Stamatoyannopoulou. 1985. Treatment of baboon with vinblastine: insights into the mechanism of pharmacologic stimulation of HbF in the adult. Blood 66: 456– 459. 24 Perrine, S., Y. W. Kan, M. F. Greene, E. Rubin, S. Cooper, R. Cohen, C. Roman, A. Rudolph & D. V. Faller. 1987. Inhibition of fetal globin gene switching in vivo in human and ovine fetuses. Prog. Clin. Biol. Res. 251: 545– 554. 25 Al-Khatti, A., R. W. Veith, T. Papayannopoulou, E. F. Fritsch, E. Goldwasser & E. Stamatoyannopoulou. 1987. Stimulation of fetal hemoglobin synthesis by erythro-poietin in baboons. N. Engl. J. Med. 317: 415– 420. 26 Torrealba-de Ron, A. T., T. Papayannopoulou, M. S. Knapp, M. F. Fu, G. Knitter & G. Stamatoyannopoulos. 1984. Perturbations in erythroid marrow progenitor cell pool may play a role in augmentation of HbF by 5-azacytidine. Blood 63: 201. 27 Humphries, R. K., G. Dover, N. S. Young, J. G. Moore, S. Charache, T. Ley & A. W. Nienhuis. 1985. 5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin. J. Clin. Invest. 75: 547. Citing Literature Volume565, Issue1Sickle Cell DiseaseJuly 1989Pages 222-226 ReferencesRelatedInformation" @default.
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