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- W2074400711 abstract "Despite the plethora of reports that demonstrate plasticity in the mammalian cerebral cortex, the characterization of the cellular mechanisms that mediate it is sparse. Here, we show that the magnitude of the experience-dependent regulation of vesicular zinc is significantly increased through enriched-environment housing. Mice were reared either in a deprived environment and subsequently housed in deprived, minimally enriched, or enriched conditions after the removal of the c-row of vibrissae or reared in an enriched environment before and after vibrissae removal. Levels of vesicular zinc were assessed in deprived and nondeprived barrels 6 h to 14 d after vibrissae removal. We found that housing in enriched environmental conditions resulted in a greater change in vesicular zinc levels than did other housing conditions; however, this effect was dependent on both the magnitude and duration of enrichment. Our data indicate that enriched-environment housing has profound effects on the regulation of vesicular zinc that occurs concurrently with experience-dependent plasticity, suggesting a role for zinc in the multitude of cortical modifications associated with enriched environments." @default.
- W2074400711 created "2016-06-24" @default.
- W2074400711 creator A5050071396 @default.
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- W2074400711 date "2008-12-17" @default.
- W2074400711 modified "2023-10-03" @default.
- W2074400711 title "Enhanced Plasticity in Zincergic, Cortical Circuits after Exposure to Enriched Environments" @default.
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- W2074400711 doi "https://doi.org/10.1523/jneurosci.4645-08.2008" @default.
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