Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074403754> ?p ?o ?g. }
- W2074403754 endingPage "60" @default.
- W2074403754 startingPage "51" @default.
- W2074403754 abstract "Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to adversely impact the central nervous system, especially with respect to learning and memory. However, the precise effect and specific mechanisms have not been fully elucidated. In the present study, pregnant Sprague-Dawley rats were orally administered with BPA at 0.05, 0.5, 5 or 50 mg/kg·body weight (BW) per day from embryonic day 9 (E 9) to E 20. We examined the effects of maternal BPA exposure on memory and synaptic structure in the hippocampus of male offspring at postnatal day (PND) 21. Maternal BPA exposure significantly affected locomotor activity, exploratory habits, and emotional behavior in open field test, and increased reference and especially working memory errors in the radial arm maze during the postnatal developing stage. Maternal BPA exposure had an adverse effect on synaptic structure, including a widened synaptic cleft, a thinned postsynaptic density (PSD), unclear synaptic surface and disappeared synaptic vesicles. Furthermore, maternal BPA exposure decreased the mRNA and protein expressions of synaptophysin, PSD-95, spinophilin, GluR1 and NMDAR1 in the hippocampus of male offspring on PND 21. These results showed that fetal growth and development was more sensitive to BPA exposure. The decreased learning and memory induced by maternal exposure to BPA in this study may be involved in synaptic plasticity alteration." @default.
- W2074403754 created "2016-06-24" @default.
- W2074403754 creator A5007857117 @default.
- W2074403754 creator A5016177837 @default.
- W2074403754 creator A5030848147 @default.
- W2074403754 creator A5068522021 @default.
- W2074403754 creator A5075070081 @default.
- W2074403754 creator A5077000248 @default.
- W2074403754 creator A5088461704 @default.
- W2074403754 date "2014-08-01" @default.
- W2074403754 modified "2023-10-16" @default.
- W2074403754 title "Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A" @default.
- W2074403754 cites W1491115957 @default.
- W2074403754 cites W1543786573 @default.
- W2074403754 cites W1624178692 @default.
- W2074403754 cites W1645161804 @default.
- W2074403754 cites W1965410558 @default.
- W2074403754 cites W1965635592 @default.
- W2074403754 cites W1966037459 @default.
- W2074403754 cites W1967211742 @default.
- W2074403754 cites W1967620846 @default.
- W2074403754 cites W1970227809 @default.
- W2074403754 cites W1975462660 @default.
- W2074403754 cites W1976182007 @default.
- W2074403754 cites W1976871715 @default.
- W2074403754 cites W1981000354 @default.
- W2074403754 cites W1982155011 @default.
- W2074403754 cites W1992285770 @default.
- W2074403754 cites W1992498121 @default.
- W2074403754 cites W1994836833 @default.
- W2074403754 cites W1996002076 @default.
- W2074403754 cites W2005354224 @default.
- W2074403754 cites W2005704396 @default.
- W2074403754 cites W2013068635 @default.
- W2074403754 cites W2016527659 @default.
- W2074403754 cites W2018381563 @default.
- W2074403754 cites W2018765209 @default.
- W2074403754 cites W2024378715 @default.
- W2074403754 cites W2027600022 @default.
- W2074403754 cites W2029015906 @default.
- W2074403754 cites W2038690499 @default.
- W2074403754 cites W2041719197 @default.
- W2074403754 cites W2046294176 @default.
- W2074403754 cites W2052435478 @default.
- W2074403754 cites W2052927712 @default.
- W2074403754 cites W2055456545 @default.
- W2074403754 cites W2056456647 @default.
- W2074403754 cites W2057851953 @default.
- W2074403754 cites W2058874386 @default.
- W2074403754 cites W2058996526 @default.
- W2074403754 cites W2060138687 @default.
- W2074403754 cites W2064854818 @default.
- W2074403754 cites W2066683636 @default.
- W2074403754 cites W2066839073 @default.
- W2074403754 cites W2067216327 @default.
- W2074403754 cites W2067753015 @default.
- W2074403754 cites W2069164790 @default.
- W2074403754 cites W2070823218 @default.
- W2074403754 cites W2079724894 @default.
- W2074403754 cites W2081746977 @default.
- W2074403754 cites W2083549550 @default.
- W2074403754 cites W2085280717 @default.
- W2074403754 cites W2088239473 @default.
- W2074403754 cites W2088646591 @default.
- W2074403754 cites W2090604814 @default.
- W2074403754 cites W2094833185 @default.
- W2074403754 cites W2098064603 @default.
- W2074403754 cites W2098440133 @default.
- W2074403754 cites W2104260362 @default.
- W2074403754 cites W2108214698 @default.
- W2074403754 cites W2112484512 @default.
- W2074403754 cites W2114570899 @default.
- W2074403754 cites W2117522169 @default.
- W2074403754 cites W2119269908 @default.
- W2074403754 cites W2133083344 @default.
- W2074403754 cites W2136916247 @default.
- W2074403754 cites W2138910339 @default.
- W2074403754 cites W2141114982 @default.
- W2074403754 cites W2147644580 @default.
- W2074403754 cites W2148428145 @default.
- W2074403754 cites W2151572760 @default.
- W2074403754 cites W2155715182 @default.
- W2074403754 cites W2158159969 @default.
- W2074403754 cites W2161448985 @default.
- W2074403754 cites W2162400338 @default.
- W2074403754 cites W2163478251 @default.
- W2074403754 cites W2170121431 @default.
- W2074403754 cites W2253928272 @default.
- W2074403754 doi "https://doi.org/10.1016/j.tox.2014.05.001" @default.
- W2074403754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24820113" @default.
- W2074403754 hasPublicationYear "2014" @default.
- W2074403754 type Work @default.
- W2074403754 sameAs 2074403754 @default.
- W2074403754 citedByCount "51" @default.
- W2074403754 countsByYear W20744037542014 @default.
- W2074403754 countsByYear W20744037542015 @default.
- W2074403754 countsByYear W20744037542016 @default.
- W2074403754 countsByYear W20744037542017 @default.