FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074420220> ?p ?o ?g. }

• W2074420220 endingPage "535" @default.
• W2074420220 startingPage "528" @default.
• W2074420220 abstract "During inflammation, neutrophils, basophils, and eosinophils release cell type-specific mediators and proteases through signaling molecules, such as G protein-coupled receptors and ion channels. As such, ion channels and receptors, including G protein-coupled receptors, are common drug targets.We sought to identify, for the first time, ion channels and receptors preferentially expressed by each granulocyte subtype.Using GeneChip, we compared approximately 20,000 transcripts present in 7 leukocyte types, platelets, mast cells, and fibroblasts to identify granulocyte subtype-selective transcripts for receptors and ion channels. Granulocyte subtype-selective transcripts were chosen on the basis of several conditions, such as the transcript having a 5-fold or greater expression level compared with the maximum level of other leukocytes.Fifty-one transcripts were chosen to be preferentially expressed by each granulocyte subtype. Seventeen of the 51 transcripts have not been previously reported as granulocyte subtype selective. Among the 17 receptors and ion channels, 6 were basophil selective, eosinophil selective, or both and were not highly expressed by other organs, indicating that they might be potential targets for antiallergy drugs.Use of this database of potential cell type-selective drug targets should minimize the efforts required for pharmaceutical development." @default.
• W2074420220 created "2016-06-24" @default.
• W2074420220 creator A5009023927 @default.
• W2074420220 creator A5015578380 @default.
• W2074420220 creator A5019545541 @default.
• W2074420220 creator A5019592349 @default.
• W2074420220 creator A5023837646 @default.
• W2074420220 creator A5024920403 @default.
• W2074420220 creator A5038209866 @default.
• W2074420220 creator A5040284754 @default.
• W2074420220 creator A5044502423 @default.
• W2074420220 creator A5054668950 @default.
• W2074420220 date "2004-03-01" @default.
• W2074420220 modified "2023-10-11" @default.
• W2074420220 title "Identification of granulocyte subtype–selective receptors and ion channels by using a high-density oligonucleotide probe array" @default.
• W2074420220 cites W1915669977 @default.
• W2074420220 cites W1939198615 @default.
• W2074420220 cites W1960023095 @default.
• W2074420220 cites W1963751483 @default.
• W2074420220 cites W1970733430 @default.
• W2074420220 cites W1995089537 @default.
• W2074420220 cites W2005061481 @default.
• W2074420220 cites W2013687663 @default.
• W2074420220 cites W2023719869 @default.
• W2074420220 cites W2027184995 @default.
• W2074420220 cites W2038624559 @default.
• W2074420220 cites W2042317690 @default.
• W2074420220 cites W2045915905 @default.
• W2074420220 cites W2053768146 @default.
• W2074420220 cites W2062456152 @default.
• W2074420220 cites W2071957953 @default.
• W2074420220 cites W2074370114 @default.
• W2074420220 cites W2101790789 @default.
• W2074420220 cites W2103195813 @default.
• W2074420220 cites W2106334460 @default.
• W2074420220 cites W2108244474 @default.
• W2074420220 cites W2118722633 @default.
• W2074420220 cites W2127230663 @default.
• W2074420220 cites W2127855108 @default.
• W2074420220 cites W2129259968 @default.
• W2074420220 cites W2160472622 @default.
• W2074420220 cites W2164368419 @default.
• W2074420220 cites W2165928443 @default.
• W2074420220 cites W2166893697 @default.
• W2074420220 cites W2168909179 @default.
• W2074420220 cites W2171573307 @default.
• W2074420220 cites W2262618850 @default.
• W2074420220 cites W2397083413 @default.
• W2074420220 cites W4205856710 @default.
• W2074420220 cites W89483841 @default.
• W2074420220 doi "https://doi.org/10.1016/j.jaci.2003.12.036" @default.
• W2074420220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15007357" @default.
• W2074420220 hasPublicationYear "2004" @default.
• W2074420220 type Work @default.
• W2074420220 sameAs 2074420220 @default.
• W2074420220 citedByCount "51" @default.
• W2074420220 countsByYear W20744202202013 @default.
• W2074420220 countsByYear W20744202202014 @default.
• W2074420220 countsByYear W20744202202016 @default.
• W2074420220 countsByYear W20744202202017 @default.
• W2074420220 countsByYear W20744202202018 @default.
• W2074420220 countsByYear W20744202202019 @default.
• W2074420220 crossrefType "journal-article" @default.
• W2074420220 hasAuthorship W2074420220A5009023927 @default.
• W2074420220 hasAuthorship W2074420220A5015578380 @default.
• W2074420220 hasAuthorship W2074420220A5019545541 @default.
• W2074420220 hasAuthorship W2074420220A5019592349 @default.
• W2074420220 hasAuthorship W2074420220A5023837646 @default.
• W2074420220 hasAuthorship W2074420220A5024920403 @default.
• W2074420220 hasAuthorship W2074420220A5038209866 @default.
• W2074420220 hasAuthorship W2074420220A5040284754 @default.
• W2074420220 hasAuthorship W2074420220A5044502423 @default.
• W2074420220 hasAuthorship W2074420220A5054668950 @default.
• W2074420220 hasConcept C141105273 @default.
• W2074420220 hasConcept C153911025 @default.
• W2074420220 hasConcept C159654299 @default.
• W2074420220 hasConcept C170493617 @default.
• W2074420220 hasConcept C181199279 @default.
• W2074420220 hasConcept C182220744 @default.
• W2074420220 hasConcept C185592680 @default.
• W2074420220 hasConcept C203014093 @default.
• W2074420220 hasConcept C2776042228 @default.
• W2074420220 hasConcept C2777037409 @default.
• W2074420220 hasConcept C2777456892 @default.
• W2074420220 hasConcept C2777983669 @default.
• W2074420220 hasConcept C50254741 @default.
• W2074420220 hasConcept C55493867 @default.
• W2074420220 hasConcept C86803240 @default.
• W2074420220 hasConcept C95444343 @default.
• W2074420220 hasConcept C98274493 @default.
• W2074420220 hasConceptScore W2074420220C141105273 @default.
• W2074420220 hasConceptScore W2074420220C153911025 @default.
• W2074420220 hasConceptScore W2074420220C159654299 @default.
• W2074420220 hasConceptScore W2074420220C170493617 @default.
• W2074420220 hasConceptScore W2074420220C181199279 @default.
• W2074420220 hasConceptScore W2074420220C182220744 @default.
• W2074420220 hasConceptScore W2074420220C185592680 @default.
• W2074420220 hasConceptScore W2074420220C203014093 @default.

• next