FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074421881> ?p ?o ?g. }

• W2074421881 abstract "Abstract In vitro studies have shown that curcumin, a polyphenol from the culinary component turmeric, has strong anticancer properties. However, there is no consensus on its therapeutic effect in human. Our earlier experiments involving implanted murine melanoma B16F10 cells in the neck or brain of syngeneic C57BL6 mice showed that tail vein injection of curcumin blocks formation of lesions and tumor in these mice. However, such treatment was ineffective in eliminating established tumors that already occupied ≤10% of brain volume. Possible reasons include low solubility and rapid metabolism of curcumin in vivo . To increase its efficacy, we have linked curcumin through a cleavable arm to an antibody (Ab) against the melanoma surface antigen Muc18. The antibody‐coupled curcumin was 230‐fold more effective in eliminating B16F10 cells in vitro , and in vivo , it rapidly decimated established, B16F10‐evoked brain tumors, enabling the rescued mice to live normally far beyond 90 days from implantation of cancer cells. In contrast, mice treated with Muc18 Ab alone died of brain tumor within a month. In B16F10 cells, curcumin‐Ab (adduct) treatment caused a dramatic inhibition of NF‐kB: a transcription factor that is constitutively activated in cancer cells. Furthermore, overexpression of NF‐kB in the B16F10 cells blocked adduct‐evoked stimulation of caspase‐3/7 activity. Thus, by suppressing NF‐kB, the curcumin adduct inhibits other downstream tumor‐promoting proteins, thereby eliminating the B16F10 cells. Our study submits a novel yet generally applicable strategy of converting curcumin into a potent anticancer agent and provides a mechanistic framework for its action." @default.
• W2074421881 created "2016-06-24" @default.
• W2074421881 creator A5031395760 @default.
• W2074421881 creator A5050697108 @default.
• W2074421881 creator A5059921154 @default.
• W2074421881 creator A5061695338 @default.
• W2074421881 creator A5075262381 @default.
• W2074421881 creator A5077564989 @default.
• W2074421881 creator A5089147335 @default.
• W2074421881 date "2012-01-03" @default.
• W2074421881 modified "2023-10-18" @default.
• W2074421881 title "Coupling to a cancer cell-specific antibody potentiates tumoricidal properties of curcumin" @default.
• W2074421881 cites W1559213768 @default.
• W2074421881 cites W1592789700 @default.
• W2074421881 cites W1976942216 @default.
• W2074421881 cites W1980828424 @default.
• W2074421881 cites W1982397837 @default.
• W2074421881 cites W1985229083 @default.
• W2074421881 cites W1987338970 @default.
• W2074421881 cites W1990351531 @default.
• W2074421881 cites W1993183577 @default.
• W2074421881 cites W1994925991 @default.
• W2074421881 cites W1995043836 @default.
• W2074421881 cites W2003233498 @default.
• W2074421881 cites W2007456673 @default.
• W2074421881 cites W2015837249 @default.
• W2074421881 cites W2016288274 @default.
• W2074421881 cites W2018023891 @default.
• W2074421881 cites W2018922462 @default.
• W2074421881 cites W2020374958 @default.
• W2074421881 cites W2022180541 @default.
• W2074421881 cites W2028556682 @default.
• W2074421881 cites W2033431239 @default.
• W2074421881 cites W2033629987 @default.
• W2074421881 cites W2050912412 @default.
• W2074421881 cites W2054498037 @default.
• W2074421881 cites W2057523433 @default.
• W2074421881 cites W2057687779 @default.
• W2074421881 cites W2072561192 @default.
• W2074421881 cites W2081156392 @default.
• W2074421881 cites W2083483697 @default.
• W2074421881 cites W2083762829 @default.
• W2074421881 cites W2098259055 @default.
• W2074421881 cites W2118986158 @default.
• W2074421881 cites W2119300490 @default.
• W2074421881 cites W2120427205 @default.
• W2074421881 cites W2133346842 @default.
• W2074421881 cites W2138508372 @default.
• W2074421881 cites W2146269545 @default.
• W2074421881 cites W2152105216 @default.
• W2074421881 cites W2156156861 @default.
• W2074421881 cites W2163581722 @default.
• W2074421881 cites W2169268810 @default.
• W2074421881 doi "https://doi.org/10.1002/ijc.26479" @default.
• W2074421881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21989768" @default.
• W2074421881 hasPublicationYear "2012" @default.
• W2074421881 type Work @default.
• W2074421881 sameAs 2074421881 @default.
• W2074421881 citedByCount "19" @default.
• W2074421881 countsByYear W20744218812013 @default.
• W2074421881 countsByYear W20744218812014 @default.
• W2074421881 countsByYear W20744218812016 @default.
• W2074421881 countsByYear W20744218812017 @default.
• W2074421881 countsByYear W20744218812018 @default.
• W2074421881 countsByYear W20744218812019 @default.
• W2074421881 countsByYear W20744218812020 @default.
• W2074421881 countsByYear W20744218812021 @default.
• W2074421881 countsByYear W20744218812022 @default.
• W2074421881 crossrefType "journal-article" @default.
• W2074421881 hasAuthorship W2074421881A5031395760 @default.
• W2074421881 hasAuthorship W2074421881A5050697108 @default.
• W2074421881 hasAuthorship W2074421881A5059921154 @default.
• W2074421881 hasAuthorship W2074421881A5061695338 @default.
• W2074421881 hasAuthorship W2074421881A5075262381 @default.
• W2074421881 hasAuthorship W2074421881A5077564989 @default.
• W2074421881 hasAuthorship W2074421881A5089147335 @default.
• W2074421881 hasBestOaLocation W20744218811 @default.
• W2074421881 hasConcept C121608353 @default.
• W2074421881 hasConcept C126322002 @default.
• W2074421881 hasConcept C150903083 @default.
• W2074421881 hasConcept C159654299 @default.
• W2074421881 hasConcept C185592680 @default.
• W2074421881 hasConcept C202751555 @default.
• W2074421881 hasConcept C203014093 @default.
• W2074421881 hasConcept C207001950 @default.
• W2074421881 hasConcept C2777658100 @default.
• W2074421881 hasConcept C2778250585 @default.
• W2074421881 hasConcept C502942594 @default.
• W2074421881 hasConcept C55493867 @default.
• W2074421881 hasConcept C71924100 @default.
• W2074421881 hasConcept C86803240 @default.
• W2074421881 hasConcept C96232424 @default.
• W2074421881 hasConcept C98274493 @default.
• W2074421881 hasConceptScore W2074421881C121608353 @default.
• W2074421881 hasConceptScore W2074421881C126322002 @default.
• W2074421881 hasConceptScore W2074421881C150903083 @default.
• W2074421881 hasConceptScore W2074421881C159654299 @default.
• W2074421881 hasConceptScore W2074421881C185592680 @default.
• W2074421881 hasConceptScore W2074421881C202751555 @default.
• W2074421881 hasConceptScore W2074421881C203014093 @default.

• next