Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074423009> ?p ?o ?g. }
- W2074423009 endingPage "148" @default.
- W2074423009 startingPage "130" @default.
- W2074423009 abstract "Label-free electrochemical (EC) protein biosensors that derive electrical signal from redox-active amino acid (AA) residues can avoid disruption of delicate protein structures, and thus provide a great opportunity to reveal valid information about protein functions. However, the challenge is that such a signal is usually very limited due to the sluggish EC reaction of free AAs on most common electrodes and slow electron-transfer rates from the deeply-buried AA residues in a protein to the electrode. Signal enhancement therefore becomes crucial. We first survey recent progress in this area. We present a signal-enhancing system that relies on the electrocatalytic oxidation of tyrosine mediated by osmium bipyridine or phenoxazine complexes. We describe several applications of label-free protein EC biosensors based on this detection principle for the analysis of protein functions, including the monitoring of protein-conformation change, study of ligand/protein binding, and detection of protein oxidative damage and protein phosphorylation. We describe related works on protein-function analysis using other signal-enhancing methods. The results suggest that label-free EC protein biosensors are suitable for the rapid survey of protein functions due to their fast response, ease of integration, cost effectiveness and convenience. Proof-of-concept work on the application of our system is paving the way for bio-analytical detections and protein-function analysis in future work." @default.
- W2074423009 created "2016-06-24" @default.
- W2074423009 creator A5001603792 @default.
- W2074423009 creator A5046763543 @default.
- W2074423009 creator A5081010731 @default.
- W2074423009 date "2012-10-01" @default.
- W2074423009 modified "2023-10-03" @default.
- W2074423009 title "Electrocatalytic oxidation of tyrosines shows signal enhancement in label-free protein biosensors" @default.
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