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• W2074429985 abstract "Transmembrane (TM) proteins constitute 15–30% of the genome, but <1% of the structures in the Protein Data Bank. This discrepancy is disturbing, and emphasizes that structure determination of TM proteins remains challenging. The challenge is greatest for proteins from eukaryotes, the structures of which remain intractable despite tremendous advances that have been made towards structure determination of bacterial TM proteins. Notably, >50% of the membrane protein families in eukaryotes lack bacterial homologs. Therefore, it is conceivable that many more years will elapse before high-resolution structures of eukaryotic TM proteins emerge. Until then, integrated approaches that combine biochemical and computational analyses with low-resolution structures are likely to have increasingly important roles in providing frameworks for the mechanistic understanding of membrane-protein structure and function. Transmembrane (TM) proteins constitute 15–30% of the genome, but <1% of the structures in the Protein Data Bank. This discrepancy is disturbing, and emphasizes that structure determination of TM proteins remains challenging. The challenge is greatest for proteins from eukaryotes, the structures of which remain intractable despite tremendous advances that have been made towards structure determination of bacterial TM proteins. Notably, >50% of the membrane protein families in eukaryotes lack bacterial homologs. Therefore, it is conceivable that many more years will elapse before high-resolution structures of eukaryotic TM proteins emerge. Until then, integrated approaches that combine biochemical and computational analyses with low-resolution structures are likely to have increasingly important roles in providing frameworks for the mechanistic understanding of membrane-protein structure and function." @default.
• W2074429985 created "2016-06-24" @default.
• W2074429985 creator A5031768744 @default.
• W2074429985 creator A5037671858 @default.
• W2074429985 creator A5059066569 @default.
• W2074429985 date "2006-02-01" @default.
• W2074429985 modified "2023-09-26" @default.
• W2074429985 title "Transmembrane protein structures without X-rays" @default.
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• W2074429985 cites W1521146215 @default.
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• W2074429985 cites W1544899066 @default.
• W2074429985 cites W1592442520 @default.
• W2074429985 cites W1805989424 @default.
• W2074429985 cites W1947778485 @default.
• W2074429985 cites W1963570264 @default.
• W2074429985 cites W1966103442 @default.
• W2074429985 cites W1966556727 @default.
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• W2074429985 cites W1976533269 @default.
• W2074429985 cites W1989661323 @default.
• W2074429985 cites W1994373739 @default.
• W2074429985 cites W1994977779 @default.
• W2074429985 cites W2000489928 @default.
• W2074429985 cites W2002547620 @default.
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• W2074429985 doi "https://doi.org/10.1016/j.tibs.2005.12.005" @default.
• W2074429985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16406532" @default.
• W2074429985 hasPublicationYear "2006" @default.
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