FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074443277> ?p ?o ?g. }

• W2074443277 endingPage "353" @default.
• W2074443277 startingPage "344" @default.
• W2074443277 abstract "Mammalian tooth development depends on activation of odontogenic potential in the presumptive dental mesenchyme by the Msx1 and Pax9 transcription factors. We recently reported that the zinc finger transcription factor Osr2 was expressed in a lingual-to-buccal gradient pattern surrounding the developing mouse molar tooth germs and mice lacking Osr2 developed supernumerary teeth lingual to their molars. We report here generation of a gene-targeted mouse strain that allows conditional inactivation of Pax9 and subsequent activation of expression of Osr2 in the developing tooth mesenchyme from the Pax9 locus. Expression of Osr2 from one copy of the Pax9 gene did not disrupt normal tooth development but was sufficient to suppress supernumerary tooth formation in the Osr2−/− mutant mice. We found that endogenous Osr2 mRNA expression was significantly downregulated in the developing tooth mesenchyme in Pax9del/del mice. Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 and Msx1 mRNA expression in the developing tooth mesenchyme, similar to that in Pax9del/del mutants but in contrast to the rescue of tooth morphogenesis in Msx1−/−Osr2−/− double mutant mice. Furthermore, we found that Osr2 formed stable protein complexes with the Msx1 protein and interacted weakly with the Pax9 protein in co-transfected cells. These data indicate that Osr2 acts downstream of Pax9 and patterns the mesenchymal odontogenic field through protein–protein interactions with Msx1 and Pax9 during early tooth development." @default.
• W2074443277 created "2016-06-24" @default.
• W2074443277 creator A5005118632 @default.
• W2074443277 creator A5019190546 @default.
• W2074443277 creator A5031767581 @default.
• W2074443277 creator A5046166835 @default.
• W2074443277 creator A5050198479 @default.
• W2074443277 creator A5051159287 @default.
• W2074443277 creator A5052243820 @default.
• W2074443277 creator A5086609859 @default.
• W2074443277 date "2011-05-01" @default.
• W2074443277 modified "2023-10-14" @default.
• W2074443277 title "Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field" @default.
• W2074443277 cites W1631640545 @default.
• W2074443277 cites W1772573500 @default.
• W2074443277 cites W1872096893 @default.
• W2074443277 cites W1963641861 @default.
• W2074443277 cites W1965932514 @default.
• W2074443277 cites W1975423981 @default.
• W2074443277 cites W1981255410 @default.
• W2074443277 cites W1986469118 @default.
• W2074443277 cites W1991382572 @default.
• W2074443277 cites W1996875432 @default.
• W2074443277 cites W1998918890 @default.
• W2074443277 cites W2009159412 @default.
• W2074443277 cites W2009487182 @default.
• W2074443277 cites W2009760295 @default.
• W2074443277 cites W2011179743 @default.
• W2074443277 cites W2011257584 @default.
• W2074443277 cites W2021258941 @default.
• W2074443277 cites W2025234765 @default.
• W2074443277 cites W2027582069 @default.
• W2074443277 cites W2030718399 @default.
• W2074443277 cites W2034717801 @default.
• W2074443277 cites W2040118243 @default.
• W2074443277 cites W2051843832 @default.
• W2074443277 cites W2052485937 @default.
• W2074443277 cites W2058172887 @default.
• W2074443277 cites W2069484009 @default.
• W2074443277 cites W2083925556 @default.
• W2074443277 cites W2106598628 @default.
• W2074443277 cites W2107504080 @default.
• W2074443277 cites W2107560148 @default.
• W2074443277 cites W2113198452 @default.
• W2074443277 cites W2117577488 @default.
• W2074443277 cites W2118895891 @default.
• W2074443277 cites W2119531737 @default.
• W2074443277 cites W2120335917 @default.
• W2074443277 cites W2122702776 @default.
• W2074443277 cites W2129454448 @default.
• W2074443277 cites W2132650229 @default.
• W2074443277 cites W2137494284 @default.
• W2074443277 cites W2153726199 @default.
• W2074443277 cites W2158505435 @default.
• W2074443277 cites W2162844628 @default.
• W2074443277 doi "https://doi.org/10.1016/j.ydbio.2011.03.012" @default.
• W2074443277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081931" @default.
• W2074443277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21420399" @default.
• W2074443277 hasPublicationYear "2011" @default.
• W2074443277 type Work @default.
• W2074443277 sameAs 2074443277 @default.
• W2074443277 citedByCount "45" @default.
• W2074443277 countsByYear W20744432772012 @default.
• W2074443277 countsByYear W20744432772013 @default.
• W2074443277 countsByYear W20744432772014 @default.
• W2074443277 countsByYear W20744432772015 @default.
• W2074443277 countsByYear W20744432772016 @default.
• W2074443277 countsByYear W20744432772017 @default.
• W2074443277 countsByYear W20744432772018 @default.
• W2074443277 countsByYear W20744432772019 @default.
• W2074443277 countsByYear W20744432772020 @default.
• W2074443277 countsByYear W20744432772021 @default.
• W2074443277 countsByYear W20744432772022 @default.
• W2074443277 crossrefType "journal-article" @default.
• W2074443277 hasAuthorship W2074443277A5005118632 @default.
• W2074443277 hasAuthorship W2074443277A5019190546 @default.
• W2074443277 hasAuthorship W2074443277A5031767581 @default.
• W2074443277 hasAuthorship W2074443277A5046166835 @default.
• W2074443277 hasAuthorship W2074443277A5050198479 @default.
• W2074443277 hasAuthorship W2074443277A5051159287 @default.
• W2074443277 hasAuthorship W2074443277A5052243820 @default.
• W2074443277 hasAuthorship W2074443277A5086609859 @default.
• W2074443277 hasBestOaLocation W20744432771 @default.
• W2074443277 hasConcept C104317684 @default.
• W2074443277 hasConcept C143065580 @default.
• W2074443277 hasConcept C198826908 @default.
• W2074443277 hasConcept C2776340970 @default.
• W2074443277 hasConcept C54355233 @default.
• W2074443277 hasConcept C86803240 @default.
• W2074443277 hasConcept C95444343 @default.
• W2074443277 hasConcept C97037327 @default.
• W2074443277 hasConceptScore W2074443277C104317684 @default.
• W2074443277 hasConceptScore W2074443277C143065580 @default.
• W2074443277 hasConceptScore W2074443277C198826908 @default.
• W2074443277 hasConceptScore W2074443277C2776340970 @default.
• W2074443277 hasConceptScore W2074443277C54355233 @default.
• W2074443277 hasConceptScore W2074443277C86803240 @default.
• W2074443277 hasConceptScore W2074443277C95444343 @default.

• next