Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074447982> ?p ?o ?g. }
- W2074447982 endingPage "3058" @default.
- W2074447982 startingPage "3037" @default.
- W2074447982 abstract "The predominant function of the tumor suppressor p53 is transcriptional regulation. It is generally accepted that p53-dependent transcriptional activation occurs by binding to a specific recognition site in promoters of target genes. Additionally, several models for p53-dependent transcriptional repression have been postulated. Here, we evaluate these models based on a computational meta-analysis of genome-wide data. Surprisingly, several major models of p53-dependent gene regulation are implausible. Meta-analysis of large-scale data is unable to confirm reports on directly repressed p53 target genes and falsifies models of direct repression. This notion is supported by experimental re-analysis of representative genes reported as directly repressed by p53. Therefore, p53 is not a direct repressor of transcription, but solely activates its target genes. Moreover, models based on interference of p53 with activating transcription factors as well as models based on the function of ncRNAs are also not supported by the meta-analysis. As an alternative to models of direct repression, the meta-analysis leads to the conclusion that p53 represses transcription indirectly by activation of the p53-p21-DREAM/RB pathway." @default.
- W2074447982 created "2016-06-24" @default.
- W2074447982 creator A5012168038 @default.
- W2074447982 creator A5013602009 @default.
- W2074447982 creator A5043215484 @default.
- W2074447982 date "2014-10-01" @default.
- W2074447982 modified "2023-10-17" @default.
- W2074447982 title "The transcription factor p53: Not a repressor, solely an activator" @default.
- W2074447982 cites W1271723105 @default.
- W2074447982 cites W1493260667 @default.
- W2074447982 cites W1498586399 @default.
- W2074447982 cites W1502271664 @default.
- W2074447982 cites W1516909359 @default.
- W2074447982 cites W1522060570 @default.
- W2074447982 cites W1564983080 @default.
- W2074447982 cites W1565339590 @default.
- W2074447982 cites W1581058135 @default.
- W2074447982 cites W1581523186 @default.
- W2074447982 cites W1581569435 @default.
- W2074447982 cites W1591281137 @default.
- W2074447982 cites W1604195255 @default.
- W2074447982 cites W1680634601 @default.
- W2074447982 cites W170856041 @default.
- W2074447982 cites W1752995067 @default.
- W2074447982 cites W1784517069 @default.
- W2074447982 cites W1790840575 @default.
- W2074447982 cites W1823168351 @default.
- W2074447982 cites W1824644433 @default.
- W2074447982 cites W1858630497 @default.
- W2074447982 cites W1899719383 @default.
- W2074447982 cites W1911008171 @default.
- W2074447982 cites W1928064989 @default.
- W2074447982 cites W1948249218 @default.
- W2074447982 cites W1963911710 @default.
- W2074447982 cites W1964190328 @default.
- W2074447982 cites W1964197602 @default.
- W2074447982 cites W1964311653 @default.
- W2074447982 cites W1964675032 @default.
- W2074447982 cites W1964719993 @default.
- W2074447982 cites W1964852940 @default.
- W2074447982 cites W1965841186 @default.
- W2074447982 cites W1966163762 @default.
- W2074447982 cites W1967529389 @default.
- W2074447982 cites W1967659443 @default.
- W2074447982 cites W1968250598 @default.
- W2074447982 cites W1968305129 @default.
- W2074447982 cites W1969093811 @default.
- W2074447982 cites W1969711650 @default.
- W2074447982 cites W1969784891 @default.
- W2074447982 cites W1969826507 @default.
- W2074447982 cites W1969881374 @default.
- W2074447982 cites W1970462958 @default.
- W2074447982 cites W1971744593 @default.
- W2074447982 cites W1971803865 @default.
- W2074447982 cites W1972351763 @default.
- W2074447982 cites W1972646045 @default.
- W2074447982 cites W1973509755 @default.
- W2074447982 cites W1973564183 @default.
- W2074447982 cites W1974393759 @default.
- W2074447982 cites W1975228908 @default.
- W2074447982 cites W1975283890 @default.
- W2074447982 cites W1976118513 @default.
- W2074447982 cites W1976842438 @default.
- W2074447982 cites W1976878409 @default.
- W2074447982 cites W1977937759 @default.
- W2074447982 cites W1978282580 @default.
- W2074447982 cites W1978406914 @default.
- W2074447982 cites W1978510296 @default.
- W2074447982 cites W1979341432 @default.
- W2074447982 cites W1979490110 @default.
- W2074447982 cites W1980167665 @default.
- W2074447982 cites W1980669461 @default.
- W2074447982 cites W1980891354 @default.
- W2074447982 cites W1981401255 @default.
- W2074447982 cites W1981974167 @default.
- W2074447982 cites W1982718063 @default.
- W2074447982 cites W1982949972 @default.
- W2074447982 cites W1985078311 @default.
- W2074447982 cites W1986179131 @default.
- W2074447982 cites W1986245375 @default.
- W2074447982 cites W1987898954 @default.
- W2074447982 cites W1988135978 @default.
- W2074447982 cites W1988553822 @default.
- W2074447982 cites W1988919179 @default.
- W2074447982 cites W1989484829 @default.
- W2074447982 cites W1990389934 @default.
- W2074447982 cites W1991387666 @default.
- W2074447982 cites W1991407069 @default.
- W2074447982 cites W1991516981 @default.
- W2074447982 cites W1992115246 @default.
- W2074447982 cites W1993478694 @default.
- W2074447982 cites W1993519922 @default.
- W2074447982 cites W1994140496 @default.
- W2074447982 cites W1994162200 @default.
- W2074447982 cites W1994838747 @default.
- W2074447982 cites W1994968768 @default.
- W2074447982 cites W1994986666 @default.
- W2074447982 cites W1995741673 @default.