FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074448914> ?p ?o ?g. }

• W2074448914 endingPage "934" @default.
• W2074448914 startingPage "921" @default.
• W2074448914 abstract "Illumina’s Infinium HumanMethylation450 BeadChip arrays were used to examine genome-wide DNA methylation profiles in 22 sample pairs from colorectal cancer (CRC) and adjacent tissues and 19 colon tissue samples from cancer-free donors. We show that the methylation profiles of tumors and healthy tissue samples can be clearly distinguished from one another and that the main source of methylation variability is associated with disease status. We used different statistical approaches to evaluate the methylation data. In general, at the CpG-site level, we found that common CRC-specific methylation patterns consist of at least 15,667 CpG sites that were significantly different from either adjacent healthy tissue or tissue from cancer-free subjects. Of these sites, 10,342 were hypermethylated in CRC, and 5,325 were hypomethylated. Hypermethylated sites were common in the maximum number of sample pairs and were mostly located in CpG islands, where they were significantly enriched for differentially methylated regions known to be cancer-specific. In contrast, hypomethylated sites were mostly located in CpG shores and were generally sample-specific. Despite the considerable variability in methylation data, we selected a panel of 14 highly robust candidates showing methylation marks in genes SND1, ADHFE1, OPLAH, TLX2, C1orf70, ZFP64, NR5A2, and COL4A. This set was successfully cross-validated using methylation data from 209 CRC samples and 38 healthy tissue samples from The Cancer Genome Atlas consortium (AUC = 0.981 [95% CI: 0.9677–0.9939], sensitivity = 100% and specificity = 82%). In summary, this study reports a large number of loci with novel differential methylation statuses, some of which may serve as candidate markers for diagnostic purposes." @default.
• W2074448914 created "2016-06-24" @default.
• W2074448914 creator A5007410097 @default.
• W2074448914 creator A5016052822 @default.
• W2074448914 creator A5016453551 @default.
• W2074448914 creator A5018510910 @default.
• W2074448914 creator A5025982738 @default.
• W2074448914 creator A5043144908 @default.
• W2074448914 creator A5051662250 @default.
• W2074448914 creator A5058244878 @default.
• W2074448914 creator A5088329305 @default.
• W2074448914 date "2013-09-01" @default.
• W2074448914 modified "2023-10-06" @default.
• W2074448914 title "Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips" @default.
• W2074448914 cites W1498471683 @default.
• W2074448914 cites W1965337318 @default.
• W2074448914 cites W1966968113 @default.
• W2074448914 cites W1974029385 @default.
• W2074448914 cites W1974747095 @default.
• W2074448914 cites W1977823892 @default.
• W2074448914 cites W1978103128 @default.
• W2074448914 cites W1979594866 @default.
• W2074448914 cites W1989605148 @default.
• W2074448914 cites W1992862760 @default.
• W2074448914 cites W1994322947 @default.
• W2074448914 cites W1994473465 @default.
• W2074448914 cites W1994536220 @default.
• W2074448914 cites W1994777946 @default.
• W2074448914 cites W2006519998 @default.
• W2074448914 cites W2011817972 @default.
• W2074448914 cites W2011896721 @default.
• W2074448914 cites W2014432992 @default.
• W2074448914 cites W2017502278 @default.
• W2074448914 cites W2025183726 @default.
• W2074448914 cites W2033126020 @default.
• W2074448914 cites W2038492487 @default.
• W2074448914 cites W2042785886 @default.
• W2074448914 cites W2046509449 @default.
• W2074448914 cites W2048005397 @default.
• W2074448914 cites W2048113241 @default.
• W2074448914 cites W2049720180 @default.
• W2074448914 cites W2050112556 @default.
• W2074448914 cites W2054080830 @default.
• W2074448914 cites W2056183418 @default.
• W2074448914 cites W2063391184 @default.
• W2074448914 cites W2084277979 @default.
• W2074448914 cites W2084801626 @default.
• W2074448914 cites W2087198289 @default.
• W2074448914 cites W2095718447 @default.
• W2074448914 cites W2096099115 @default.
• W2074448914 cites W2099406100 @default.
• W2074448914 cites W2101170994 @default.
• W2074448914 cites W2102413929 @default.
• W2074448914 cites W2103033566 @default.
• W2074448914 cites W2103673123 @default.
• W2074448914 cites W2115578647 @default.
• W2074448914 cites W2123696077 @default.
• W2074448914 cites W2128146359 @default.
• W2074448914 cites W2128676090 @default.
• W2074448914 cites W2132601639 @default.
• W2074448914 cites W2132682597 @default.
• W2074448914 cites W2136914254 @default.
• W2074448914 cites W2137815533 @default.
• W2074448914 cites W2141105144 @default.
• W2074448914 cites W2146344304 @default.
• W2074448914 cites W2148521032 @default.
• W2074448914 cites W2150625137 @default.
• W2074448914 cites W2169903102 @default.
• W2074448914 cites W2170029176 @default.
• W2074448914 cites W2262414037 @default.
• W2074448914 cites W2328176404 @default.
• W2074448914 cites W2329888282 @default.
• W2074448914 cites W4213257593 @default.
• W2074448914 doi "https://doi.org/10.4161/epi.25577" @default.
• W2074448914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3883769" @default.
• W2074448914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23867710" @default.
• W2074448914 hasPublicationYear "2013" @default.
• W2074448914 type Work @default.
• W2074448914 sameAs 2074448914 @default.
• W2074448914 citedByCount "111" @default.
• W2074448914 countsByYear W20744489142014 @default.
• W2074448914 countsByYear W20744489142015 @default.
• W2074448914 countsByYear W20744489142016 @default.
• W2074448914 countsByYear W20744489142017 @default.
• W2074448914 countsByYear W20744489142018 @default.
• W2074448914 countsByYear W20744489142019 @default.
• W2074448914 countsByYear W20744489142020 @default.
• W2074448914 countsByYear W20744489142021 @default.
• W2074448914 countsByYear W20744489142022 @default.
• W2074448914 countsByYear W20744489142023 @default.
• W2074448914 crossrefType "journal-article" @default.
• W2074448914 hasAuthorship W2074448914A5007410097 @default.
• W2074448914 hasAuthorship W2074448914A5016052822 @default.
• W2074448914 hasAuthorship W2074448914A5016453551 @default.
• W2074448914 hasAuthorship W2074448914A5018510910 @default.
• W2074448914 hasAuthorship W2074448914A5025982738 @default.
• W2074448914 hasAuthorship W2074448914A5043144908 @default.
• W2074448914 hasAuthorship W2074448914A5051662250 @default.

• next