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• W2074457872 abstract "The commonly used volatile anesthetics, several of their metabolites, and drugs frequently employed by the anesthesiologist were screened for mutagenicity in the Salmonella/rat-liver microsomal assay system developed by Dr. B. Ames and his colleagues. Chloral hydrate, both a sedative and metabolite of trichloroethylene, was found to be weakly mutagenic. Other compounds tested including halothane, isoflurane, methoxyflurane, diazepam and chlordiazepoxide were not mutagenic. Non-volatile compounds were tested for their ability to inhibit growth of bacterial strains with decreased capacity to repair damaged DNA. None of the compounds tested inhibited the growth of DNA-repair-deficient strains relative to a strain with normal DNA-repair. Halothane and trilene were tested for direct interaction with DNA; under the experimental conditions employed, no direct interaction of these compounds and DNA could be detected." @default.
• W2074457872 created "2016-06-24" @default.
• W2074457872 creator A5050932910 @default.
• W2074457872 date "1978-01-01" @default.
• W2074457872 modified "2023-10-18" @default.
• W2074457872 title "A study of the mutagenicity of anesthetics and their metabolites" @default.
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• W2074457872 doi "https://doi.org/10.1016/0027-5107(78)90261-0" @default.
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