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- W2074481490 abstract "Zusammenfassung: Während einer 5monatigen Tamoxifentherapie (2 times 10 bzw. 2 times 20 mg/die) kommt es zu einem signifikanten Anstieg von Testosteron, LH, FSH, Östradiol, freiem Testosteron und SHBG. Der Prolaktinspiegel fällt ab. Im Ejakulat sinken innerhalb des Normwertes der pH-Wert und die Fruktose. Die Spermatozoendichte steigt signifikant an; dabei bleibt unsicher, ob mit 2 times 20 mg/die bessere Ergebnisse erzielt werden. Mit unseren bisherigen Untersuchungsmethoden war eine Auswahl der Patienten, die auf die Behandlung gut ansprechen, nicht möglich. Tamoxifen scheint bei normo-, aber auch bei hypo- und hypergonadotropen Patienten wirksam zu sein. Summary: Therapeutic Results with Tamoxifen in Oligozoospermia II. Hormonal Analysis and Semen Parameters During a five months lasting treatment with tamoxifen (2 times10 resp. 2 times 20 mg daily) a significant increase of testosterone, LH, FSH, estradiol, free testosterone and SHBG was found. The prolactin levels diminished. In semen analysis the values of pH and fructose decreased within the normal range. The sperm density increased significantly, but we could not ascertain whether a dosage of 2 times 20 mg/die will provide better therapeutic results. Furthermore the hormonal and seminal investigations described in this paper did not allow to predict those patients who would be good responders on tamoxifen therapy. Tamoxifen seems to be effective in normo-, but also in hypo- and hypergonado-tropic patients." @default.
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- W2074481490 date "2009-04-24" @default.
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- W2074481490 title "Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie Teil II: Hormonanalysen und Ejakulatbefunde" @default.
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- W2074481490 doi "https://doi.org/10.1111/j.1439-0272.1987.tb02312.x" @default.
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