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- W2074482132 abstract "The in vitro biosynthesis of aldosterone and other 18-oxygenated corticosteroids from labeled steroid precursors was investigated by rabbit adrenal slices, homogenates and mitochondrial preparations. Exogenous 18-hydroxy-corticosterone and 18-hydroxy-11-dehydrocorticosterone were both converted to aldosterone to a limited extent only. Both corticosterone and 11-dehydrocorticosterone were efficiently 18-hydroxylated by adrenal slices and mitochondria. The two 18-hydroxylated derivatives were interconvertible. Investigation of isotope ratios of steroids synthesized in substrate pair experiments, utilizing 11-dehydrocorticosterone-4-14C and corticosterone-1,2-3H have shown, that aldosterone was formed mainly from corticosterone via 18-hydroxy-corticosterone. However, the contribution of 11-dehydrocorticosterone to aldosterone was higher than to 18-hydroxy-corticosterone. This could have been mediated through 11-dehydroaldosterone which originated from 11-dehydrocorticosterone and was shown to be efficiently converted to aldosterone in a separate incubation." @default.
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- W2074482132 date "1969-08-01" @default.
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- W2074482132 title "Unusual pathways of aldosterone biosynthesis in the rabbit adrenal" @default.
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- W2074482132 doi "https://doi.org/10.1016/0039-128x(69)90031-2" @default.
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