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- W2074489144 abstract "Androgens are essential for the development and growth of the penis, and they regulate erectile physiology by multiple mechanisms. Our goal is to provide a concise overview of the basic research and how this knowledge can be translated into a new clinical paradigm for patient management. In addition, this new paradigm may serve as a basis for stimulating constructive debate regarding the use of testosterone in men, and to promote new, innovative basic and clinical research to further understand the underlying mechanisms of androgen action in restoring erectile physiology. A literature review was performed utilizing the US National Library of Medicine’s PubMed database. On the basis of evidence derived from laboratory animal studies and clinical data, we postulate that androgen insufficiency disrupts cellular-signaling pathways and produces pathologic alterations in penile tissues, leading to erectile dysfunction. In this review, we discuss androgen-dependent cellular, molecular, and physiologic mechanisms modulating erectile function in the animal model, and the implication of this knowledge in testosterone use in the clinical setting to treat erectile dysfunction. The new clinical paradigm incorporates many of the consensed points of view discussed in traditional consensed algorithms exclusively designed for men with androgen insufficiency. There are, however, novel and innovative differences with this new clinical paradigm. This paradigm represents a fresh effort to provide mandatory and optional management strategies for men with both androgen insufficiency and erectile dysfunction. The new clinical paradigm is evidence-based and represents one of the first attempts to address a logical management plan for men with concomitant hormonal and sexual health concerns." @default.
- W2074489144 created "2016-06-24" @default.
- W2074489144 creator A5009310546 @default.
- W2074489144 creator A5014078830 @default.
- W2074489144 creator A5084333425 @default.
- W2074489144 date "2007-07-01" @default.
- W2074489144 modified "2023-10-03" @default.
- W2074489144 title "Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction" @default.
- W2074489144 cites W112918881 @default.
- W2074489144 cites W1487139504 @default.
- W2074489144 cites W1500156739 @default.
- W2074489144 cites W1502512164 @default.
- W2074489144 cites W1562814494 @default.
- W2074489144 cites W1573981241 @default.
- W2074489144 cites W1585626953 @default.
- W2074489144 cites W1587533961 @default.
- W2074489144 cites W1590654957 @default.
- W2074489144 cites W1718442556 @default.
- W2074489144 cites W1759894098 @default.
- W2074489144 cites W1808686279 @default.
- W2074489144 cites W186068 @default.
- W2074489144 cites W1927025995 @default.
- W2074489144 cites W1952063735 @default.
- W2074489144 cites W1968109225 @default.
- W2074489144 cites W1968899278 @default.
- W2074489144 cites W1969811041 @default.
- W2074489144 cites W1970474244 @default.
- W2074489144 cites W1970890772 @default.
- W2074489144 cites W1972077875 @default.
- W2074489144 cites W1973102818 @default.
- W2074489144 cites W1978940653 @default.
- W2074489144 cites W1979521526 @default.
- W2074489144 cites W1980878845 @default.
- W2074489144 cites W1984704085 @default.
- W2074489144 cites W1985005329 @default.
- W2074489144 cites W1990261556 @default.
- W2074489144 cites W1990586673 @default.
- W2074489144 cites W1993400109 @default.
- W2074489144 cites W1994273184 @default.
- W2074489144 cites W1994479220 @default.
- W2074489144 cites W1995499846 @default.
- W2074489144 cites W1997544440 @default.
- W2074489144 cites W1997825003 @default.
- W2074489144 cites W2001118572 @default.
- W2074489144 cites W2001610421 @default.
- W2074489144 cites W2001741671 @default.
- W2074489144 cites W2002642902 @default.
- W2074489144 cites W2005563447 @default.
- W2074489144 cites W2010001642 @default.
- W2074489144 cites W2010090922 @default.
- W2074489144 cites W2010902199 @default.
- W2074489144 cites W2013659715 @default.
- W2074489144 cites W2013892569 @default.
- W2074489144 cites W2013982214 @default.
- W2074489144 cites W2014527046 @default.
- W2074489144 cites W2014689988 @default.
- W2074489144 cites W2015383498 @default.
- W2074489144 cites W2017954678 @default.
- W2074489144 cites W2018431150 @default.
- W2074489144 cites W2020105514 @default.
- W2074489144 cites W2021445141 @default.
- W2074489144 cites W2023599187 @default.
- W2074489144 cites W2027109764 @default.
- W2074489144 cites W2027831030 @default.
- W2074489144 cites W2028098634 @default.
- W2074489144 cites W2028108864 @default.
- W2074489144 cites W2028173444 @default.
- W2074489144 cites W2033386047 @default.
- W2074489144 cites W2034381859 @default.
- W2074489144 cites W2035233031 @default.
- W2074489144 cites W2036592098 @default.
- W2074489144 cites W2036662131 @default.
- W2074489144 cites W2036671006 @default.
- W2074489144 cites W2037898506 @default.
- W2074489144 cites W2040056618 @default.
- W2074489144 cites W2043590202 @default.
- W2074489144 cites W2043941415 @default.
- W2074489144 cites W2046833545 @default.
- W2074489144 cites W2047242041 @default.
- W2074489144 cites W2047844006 @default.
- W2074489144 cites W2047864194 @default.
- W2074489144 cites W2050310464 @default.
- W2074489144 cites W2050638368 @default.
- W2074489144 cites W2050790795 @default.
- W2074489144 cites W2054997618 @default.
- W2074489144 cites W2056611245 @default.
- W2074489144 cites W2058009232 @default.
- W2074489144 cites W2059080935 @default.
- W2074489144 cites W2062910063 @default.
- W2074489144 cites W2064360784 @default.
- W2074489144 cites W2064549818 @default.
- W2074489144 cites W2064784013 @default.
- W2074489144 cites W2065485238 @default.
- W2074489144 cites W2065662763 @default.
- W2074489144 cites W2067205814 @default.
- W2074489144 cites W2067749656 @default.
- W2074489144 cites W2073059832 @default.
- W2074489144 cites W2074522120 @default.