Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074492282> ?p ?o ?g. }
- W2074492282 endingPage "233" @default.
- W2074492282 startingPage "223" @default.
- W2074492282 abstract "To identify Mycobacterium tuberculosis (Mtb) antigens as candidates for a subunit vaccine against tuberculosis (TB), we have employed a CD4+ T-cell expression screening method. Mtb-specific CD4+ T-cell lines from nine healthy PPD positive donors were stimulated with different antigenic substrates including autologous dendritic cells (DC) infected with Mtb, or cultured with culture filtrate proteins (CFP), and purified protein derivative of Mtb (PPD). These lines were used to screen a genomic Mtb library expressed in Escherichia coli and processed and presented by autologous DC. This screening led to the recovery of numerous T-cell antigens, including both novel and previously described antigens. One of these novel antigens, referred to as Mtb9.8 (Rv0287), was recognized by multiple T-cell lines, stimulated with either Mtb-infected DC or CFP. Using the mouse and guinea pig models of TB, high levels of IFN-γ were produced, and solid protection from Mtb challenge was observed following immunization with Mtb9.8 formulated in either AS02A or AS01B Adjuvant Systems. These results demonstrate that T-cell screening of the Mtb genome can be used to identify CD4+ T-cell antigens that are candidates for vaccine development." @default.
- W2074492282 created "2016-06-24" @default.
- W2074492282 creator A5039321722 @default.
- W2074492282 creator A5053137937 @default.
- W2074492282 creator A5060338193 @default.
- W2074492282 creator A5069555692 @default.
- W2074492282 creator A5069585538 @default.
- W2074492282 creator A5071001878 @default.
- W2074492282 creator A5073557505 @default.
- W2074492282 creator A5086176543 @default.
- W2074492282 date "2009-01-01" @default.
- W2074492282 modified "2023-10-18" @default.
- W2074492282 title "Identification of Mycobacterium tuberculosis vaccine candidates using human CD4+ T-cells expression cloning" @default.
- W2074492282 cites W1517275946 @default.
- W2074492282 cites W1553697637 @default.
- W2074492282 cites W1559734595 @default.
- W2074492282 cites W1582232949 @default.
- W2074492282 cites W1921564254 @default.
- W2074492282 cites W1942950056 @default.
- W2074492282 cites W1965142821 @default.
- W2074492282 cites W1965233383 @default.
- W2074492282 cites W1995225418 @default.
- W2074492282 cites W1995560626 @default.
- W2074492282 cites W2016042447 @default.
- W2074492282 cites W2016222350 @default.
- W2074492282 cites W2025326087 @default.
- W2074492282 cites W2026617947 @default.
- W2074492282 cites W2036616202 @default.
- W2074492282 cites W2046559260 @default.
- W2074492282 cites W2053405315 @default.
- W2074492282 cites W2053951102 @default.
- W2074492282 cites W2070633997 @default.
- W2074492282 cites W2080374458 @default.
- W2074492282 cites W2097154266 @default.
- W2074492282 cites W2100894095 @default.
- W2074492282 cites W2109484445 @default.
- W2074492282 cites W2111354206 @default.
- W2074492282 cites W2112772985 @default.
- W2074492282 cites W2116616469 @default.
- W2074492282 cites W2118978296 @default.
- W2074492282 cites W2127558739 @default.
- W2074492282 cites W2130046741 @default.
- W2074492282 cites W2130074351 @default.
- W2074492282 cites W2132657101 @default.
- W2074492282 cites W2156255370 @default.
- W2074492282 cites W2156436209 @default.
- W2074492282 cites W2157376708 @default.
- W2074492282 cites W2157605618 @default.
- W2074492282 cites W2158204548 @default.
- W2074492282 cites W2160239525 @default.
- W2074492282 cites W2163904966 @default.
- W2074492282 cites W2163964526 @default.
- W2074492282 doi "https://doi.org/10.1016/j.vaccine.2008.10.056" @default.
- W2074492282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2673800" @default.
- W2074492282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19000730" @default.
- W2074492282 hasPublicationYear "2009" @default.
- W2074492282 type Work @default.
- W2074492282 sameAs 2074492282 @default.
- W2074492282 citedByCount "28" @default.
- W2074492282 countsByYear W20744922822012 @default.
- W2074492282 countsByYear W20744922822013 @default.
- W2074492282 countsByYear W20744922822014 @default.
- W2074492282 countsByYear W20744922822016 @default.
- W2074492282 countsByYear W20744922822017 @default.
- W2074492282 countsByYear W20744922822018 @default.
- W2074492282 countsByYear W20744922822019 @default.
- W2074492282 countsByYear W20744922822022 @default.
- W2074492282 countsByYear W20744922822023 @default.
- W2074492282 crossrefType "journal-article" @default.
- W2074492282 hasAuthorship W2074492282A5039321722 @default.
- W2074492282 hasAuthorship W2074492282A5053137937 @default.
- W2074492282 hasAuthorship W2074492282A5060338193 @default.
- W2074492282 hasAuthorship W2074492282A5069555692 @default.
- W2074492282 hasAuthorship W2074492282A5069585538 @default.
- W2074492282 hasAuthorship W2074492282A5071001878 @default.
- W2074492282 hasAuthorship W2074492282A5073557505 @default.
- W2074492282 hasAuthorship W2074492282A5086176543 @default.
- W2074492282 hasBestOaLocation W20744922822 @default.
- W2074492282 hasConcept C142724271 @default.
- W2074492282 hasConcept C147483822 @default.
- W2074492282 hasConcept C159047783 @default.
- W2074492282 hasConcept C203014093 @default.
- W2074492282 hasConcept C2776090121 @default.
- W2074492282 hasConcept C2777863537 @default.
- W2074492282 hasConcept C2777975735 @default.
- W2074492282 hasConcept C2779078216 @default.
- W2074492282 hasConcept C2781069245 @default.
- W2074492282 hasConcept C71924100 @default.
- W2074492282 hasConcept C86803240 @default.
- W2074492282 hasConcept C8891405 @default.
- W2074492282 hasConcept C89423630 @default.
- W2074492282 hasConceptScore W2074492282C142724271 @default.
- W2074492282 hasConceptScore W2074492282C147483822 @default.
- W2074492282 hasConceptScore W2074492282C159047783 @default.
- W2074492282 hasConceptScore W2074492282C203014093 @default.
- W2074492282 hasConceptScore W2074492282C2776090121 @default.
- W2074492282 hasConceptScore W2074492282C2777863537 @default.
- W2074492282 hasConceptScore W2074492282C2777975735 @default.