FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074506502> ?p ?o ?g. }

• W2074506502 endingPage "360" @default.
• W2074506502 startingPage "354" @default.
• W2074506502 abstract "Despite the widespread use of pharmacological and/or interventional reperfusion therapies, recovery of cardiac function in myocardial infarction (MI) patients is often modest or even absent. Unlike classical pharmacological treatments, the use of progenitor cells could potentially restore functional tissue in regions that otherwise would form only scar. However, a major limitation of autologous cell therapy is the deleterious influence of age and cardiac risk factors on progenitor cell activity.The ENACT-AMI trial is a phase IIb, double-blind, randomized placebo-controlled trial, using transplantation of autologous early endothelial progenitor cells (EPCs) for patients who have suffered large MI. Circulating mononuclear cells (MNCs) are obtained by apheresis and subjected to differential culture for 3 days to select a population of highly regenerative, endothelial-like, culture modified MNCs (E-CMMs), often referred to as early EPCs. A total of 99 patients will be randomized to placebo (Plasma-Lyte A), autologous E-CMMs, or E-CMMs transfected with human endothelial nitric oxide synthase delivered by coronary injection into the infarct-related artery. The primary efficacy end point is change from baseline to 6 months in global left ventricular ejection fraction by cardiac MRI; secondary endpoints include regional wall motion, wall thickening, infarct volume, time to clinical worsening, and quality of life.This will be the first clinical trial to include a strategy designed to enhance the function of autologous progenitor cells by overexpressing endothelial nitric oxide synthase, and the first to use combination gene and cell therapy for the treatment of cardiac disease." @default.
• W2074506502 created "2016-06-24" @default.
• W2074506502 creator A5004200582 @default.
• W2074506502 creator A5031594150 @default.
• W2074506502 creator A5034488968 @default.
• W2074506502 creator A5047187243 @default.
• W2074506502 creator A5055812329 @default.
• W2074506502 creator A5068773395 @default.
• W2074506502 creator A5070564381 @default.
• W2074506502 creator A5080491036 @default.
• W2074506502 creator A5084924094 @default.
• W2074506502 creator A5085718584 @default.
• W2074506502 date "2010-03-01" @default.
• W2074506502 modified "2023-09-27" @default.
• W2074506502 title "Rationale and design of Enhanced Angiogenic Cell Therapy in Acute Myocardial Infarction (ENACT-AMI): The first randomized placebo-controlled trial of enhanced progenitor cell therapy for acute myocardial infarction" @default.
• W2074506502 cites W1964157625 @default.
• W2074506502 cites W1966780233 @default.
• W2074506502 cites W1974812650 @default.
• W2074506502 cites W197648304 @default.
• W2074506502 cites W1977437881 @default.
• W2074506502 cites W1988126593 @default.
• W2074506502 cites W2009485059 @default.
• W2074506502 cites W2029816723 @default.
• W2074506502 cites W2044129810 @default.
• W2074506502 cites W2045360522 @default.
• W2074506502 cites W2058195291 @default.
• W2074506502 cites W2065334138 @default.
• W2074506502 cites W2071746224 @default.
• W2074506502 cites W2074758042 @default.
• W2074506502 cites W2075344844 @default.
• W2074506502 cites W2082786908 @default.
• W2074506502 cites W2089853948 @default.
• W2074506502 cites W2098743872 @default.
• W2074506502 cites W2105001034 @default.
• W2074506502 cites W2107922629 @default.
• W2074506502 cites W2108875285 @default.
• W2074506502 cites W2111486034 @default.
• W2074506502 cites W2127872440 @default.
• W2074506502 cites W2130761693 @default.
• W2074506502 cites W2140165420 @default.
• W2074506502 cites W2140928988 @default.
• W2074506502 cites W2141654731 @default.
• W2074506502 cites W2151722542 @default.
• W2074506502 cites W2154935039 @default.
• W2074506502 cites W2163807262 @default.
• W2074506502 cites W2167595513 @default.
• W2074506502 cites W2316075782 @default.
• W2074506502 cites W4251403705 @default.
• W2074506502 doi "https://doi.org/10.1016/j.ahj.2009.12.021" @default.
• W2074506502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20211295" @default.
• W2074506502 hasPublicationYear "2010" @default.
• W2074506502 type Work @default.
• W2074506502 sameAs 2074506502 @default.
• W2074506502 citedByCount "79" @default.
• W2074506502 countsByYear W20745065022012 @default.
• W2074506502 countsByYear W20745065022013 @default.
• W2074506502 countsByYear W20745065022014 @default.
• W2074506502 countsByYear W20745065022015 @default.
• W2074506502 countsByYear W20745065022016 @default.
• W2074506502 countsByYear W20745065022017 @default.
• W2074506502 countsByYear W20745065022018 @default.
• W2074506502 countsByYear W20745065022019 @default.
• W2074506502 countsByYear W20745065022020 @default.
• W2074506502 countsByYear W20745065022021 @default.
• W2074506502 countsByYear W20745065022022 @default.
• W2074506502 countsByYear W20745065022023 @default.
• W2074506502 crossrefType "journal-article" @default.
• W2074506502 hasAuthorship W2074506502A5004200582 @default.
• W2074506502 hasAuthorship W2074506502A5031594150 @default.
• W2074506502 hasAuthorship W2074506502A5034488968 @default.
• W2074506502 hasAuthorship W2074506502A5047187243 @default.
• W2074506502 hasAuthorship W2074506502A5055812329 @default.
• W2074506502 hasAuthorship W2074506502A5068773395 @default.
• W2074506502 hasAuthorship W2074506502A5070564381 @default.
• W2074506502 hasAuthorship W2074506502A5080491036 @default.
• W2074506502 hasAuthorship W2074506502A5084924094 @default.
• W2074506502 hasAuthorship W2074506502A5085718584 @default.
• W2074506502 hasConcept C10882517 @default.
• W2074506502 hasConcept C126322002 @default.
• W2074506502 hasConcept C141071460 @default.
• W2074506502 hasConcept C164705383 @default.
• W2074506502 hasConcept C201750760 @default.
• W2074506502 hasConcept C203092338 @default.
• W2074506502 hasConcept C2778198053 @default.
• W2074506502 hasConcept C2778213512 @default.
• W2074506502 hasConcept C2779389132 @default.
• W2074506502 hasConcept C2780152582 @default.
• W2074506502 hasConcept C28328180 @default.
• W2074506502 hasConcept C2908647359 @default.
• W2074506502 hasConcept C2911091166 @default.
• W2074506502 hasConcept C500558357 @default.
• W2074506502 hasConcept C535046627 @default.
• W2074506502 hasConcept C54355233 @default.
• W2074506502 hasConcept C71924100 @default.
• W2074506502 hasConcept C78085059 @default.
• W2074506502 hasConcept C86803240 @default.
• W2074506502 hasConcept C99454951 @default.
• W2074506502 hasConceptScore W2074506502C10882517 @default.

• next