FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074520327> ?p ?o ?g. }

• W2074520327 endingPage "242" @default.
• W2074520327 startingPage "223" @default.
• W2074520327 abstract "To determine features of the steady state [Ca2+]-tension relationship in intact heart, we measured steady force and intracellular [Ca2+] ([Ca2+]i) in tetanized ferret papillary muscles. [Ca2+]i was estimated from the luminescence emitted by muscles that had been microinjected with aequorin, a Ca2+-sensitive, bioluminescent protein. We found that by raising extracellular [Ca2+] and/or by exposing muscles to the Ca2+ channel agonist Bay K 8644, tension development could be varied from rest to an apparently saturating level, at which increases in [Ca2+]i produced no further rise in force. 95% of maximal Ca2+-activated force was reached at a [Ca2+]i of 0.85 +/- 0.06 microM (mean +/- SEM; n = 7), which suggests that the sensitivity of the myofilaments to [Ca2+]i is far greater than anticipated from studies of skinned heart preparations (or from previous studies using Ca2+-sensitive microelectrodes in intact heart). Our finding that maximal force was reached by approximately 1 microM also allowed us to calculate that the steady state [Ca2+]i-tension relationship, as it might be observed in intact muscle, should be steep (Hill coefficient of greater than 4), which is consistent with the Hill coefficient estimated from the entire [Ca2+]i-tension relationship derived from families of variably activated tetani (6.08 +/- 0.68; n = 7). Finally, with regard to whether steady state measurements can be applied directly toward understanding physiological contractions, we found that the relation between steady force and [Ca2+]i obtained during tetani was steeper than that between peak force and peak [Ca2+]i observed during physiological twitches." @default.
• W2074520327 created "2016-06-24" @default.
• W2074520327 creator A5045137391 @default.
• W2074520327 creator A5046381230 @default.
• W2074520327 creator A5086776128 @default.
• W2074520327 date "1986-02-01" @default.
• W2074520327 modified "2023-10-11" @default.
• W2074520327 title "Relationship between force and intracellular [Ca2+] in tetanized mammalian heart muscle." @default.
• W2074520327 cites W1523578038 @default.
• W2074520327 cites W1963715479 @default.
• W2074520327 cites W1967107251 @default.
• W2074520327 cites W1967513994 @default.
• W2074520327 cites W1972063745 @default.
• W2074520327 cites W1974565443 @default.
• W2074520327 cites W1975547534 @default.
• W2074520327 cites W1978473572 @default.
• W2074520327 cites W1984045146 @default.
• W2074520327 cites W1996140321 @default.
• W2074520327 cites W2003290962 @default.
• W2074520327 cites W2012187456 @default.
• W2074520327 cites W2023553130 @default.
• W2074520327 cites W2047255322 @default.
• W2074520327 cites W2054584058 @default.
• W2074520327 cites W2055784873 @default.
• W2074520327 cites W2057062767 @default.
• W2074520327 cites W2065149315 @default.
• W2074520327 cites W2066125154 @default.
• W2074520327 cites W2068089024 @default.
• W2074520327 cites W2069051817 @default.
• W2074520327 cites W2094276784 @default.
• W2074520327 cites W2099444831 @default.
• W2074520327 cites W2111251415 @default.
• W2074520327 cites W2114183032 @default.
• W2074520327 cites W2115222241 @default.
• W2074520327 cites W2134321897 @default.
• W2074520327 cites W2138427708 @default.
• W2074520327 cites W2140073129 @default.
• W2074520327 cites W2140283153 @default.
• W2074520327 cites W2144374865 @default.
• W2074520327 cites W2148866893 @default.
• W2074520327 cites W2150582811 @default.
• W2074520327 cites W2154667750 @default.
• W2074520327 cites W2159197854 @default.
• W2074520327 cites W2164452266 @default.
• W2074520327 cites W2226148627 @default.
• W2074520327 cites W2414867144 @default.
• W2074520327 cites W2418488240 @default.
• W2074520327 doi "https://doi.org/10.1085/jgp.87.2.223" @default.
• W2074520327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2217602" @default.
• W2074520327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2419483" @default.
• W2074520327 hasPublicationYear "1986" @default.
• W2074520327 type Work @default.
• W2074520327 sameAs 2074520327 @default.
• W2074520327 citedByCount "189" @default.
• W2074520327 countsByYear W20745203272012 @default.
• W2074520327 countsByYear W20745203272014 @default.
• W2074520327 countsByYear W20745203272015 @default.
• W2074520327 countsByYear W20745203272016 @default.
• W2074520327 countsByYear W20745203272017 @default.
• W2074520327 countsByYear W20745203272018 @default.
• W2074520327 countsByYear W20745203272019 @default.
• W2074520327 countsByYear W20745203272020 @default.
• W2074520327 countsByYear W20745203272021 @default.
• W2074520327 countsByYear W20745203272022 @default.
• W2074520327 countsByYear W20745203272023 @default.
• W2074520327 crossrefType "journal-article" @default.
• W2074520327 hasAuthorship W2074520327A5045137391 @default.
• W2074520327 hasAuthorship W2074520327A5046381230 @default.
• W2074520327 hasAuthorship W2074520327A5086776128 @default.
• W2074520327 hasBestOaLocation W20745203271 @default.
• W2074520327 hasConcept C103486182 @default.
• W2074520327 hasConcept C105702510 @default.
• W2074520327 hasConcept C121332964 @default.
• W2074520327 hasConcept C12554922 @default.
• W2074520327 hasConcept C126322002 @default.
• W2074520327 hasConcept C134018914 @default.
• W2074520327 hasConcept C147789679 @default.
• W2074520327 hasConcept C178790620 @default.
• W2074520327 hasConcept C180016635 @default.
• W2074520327 hasConcept C185592680 @default.
• W2074520327 hasConcept C186068551 @default.
• W2074520327 hasConcept C2776050358 @default.
• W2074520327 hasConcept C2777274916 @default.
• W2074520327 hasConcept C2778996579 @default.
• W2074520327 hasConcept C28406088 @default.
• W2074520327 hasConcept C519063684 @default.
• W2074520327 hasConcept C55493867 @default.
• W2074520327 hasConcept C71924100 @default.
• W2074520327 hasConcept C79879829 @default.
• W2074520327 hasConcept C80933277 @default.
• W2074520327 hasConcept C8171440 @default.
• W2074520327 hasConcept C86803240 @default.
• W2074520327 hasConcept C97355855 @default.
• W2074520327 hasConceptScore W2074520327C103486182 @default.
• W2074520327 hasConceptScore W2074520327C105702510 @default.
• W2074520327 hasConceptScore W2074520327C121332964 @default.
• W2074520327 hasConceptScore W2074520327C12554922 @default.
• W2074520327 hasConceptScore W2074520327C126322002 @default.

• next