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• W2074533002 abstract "Parkinson's disease (PD) is a common neurodegenerative disorder of unknown etiology, the cardinal features of which include tremor, rigidity, slowness of movement and postural instability [ 1 Fahn S. Przedborski S. Rowland L.P. Merritt's neurology. Lippincott Williams & Wilkins, 2000: 679-693 Google Scholar ]. Its pathological hallmarks are the loss of the nigrostriatal dopaminergic neurons and the presence of neuronal proteinacious cytoplasmic inclusions, known as Lewy bodies [ 1 Fahn S. Przedborski S. Rowland L.P. Merritt's neurology. Lippincott Williams & Wilkins, 2000: 679-693 Google Scholar ]. Rotenone, a mitochondrial poison whose relevance to the etiology of PD is unknown, represents the most recent approach to modeling PD in rats [ 2 Betarbet R. et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 2000; 3: 1301-1306 Crossref PubMed Scopus (2906) Google Scholar ]. However, to date not enough time has passed for full evaluation of the rotenone model of PD and the published data raise several important questions pertaining to its significance and reliability." @default.
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• W2074533002 date "2003-07-01" @default.
• W2074533002 modified "2023-10-18" @default.
• W2074533002 title "The rotenone model of Parkinson's disease" @default.
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• W2074533002 doi "https://doi.org/10.1016/s0166-2236(03)00144-9" @default.
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