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• W2074535177 abstract "Emphysema is a disease of the lung parenchyma with progressive alveolar tissue destruction that leads to peripheral airspace enlargement. In this review, we discuss how mechanical forces can contribute to disease progression at various length scales. Airspace enlargement requires mechanical failure of alveolar walls. Because the lung tissue is under a pre-existing tensile stress, called prestress, the failure of a single wall results in a redistribution of the local prestress. During this process, the prestress increases on neighboring alveolar walls which in turn increases the probability that these walls also undergo mechanical failure. There are several mechanisms that can contribute to this increased probability: exceeding the failure threshold of the ECM, triggering local mechanotransduction to release enzymes, altering enzymatic reactions on ECM molecules. Next, we specifically discuss recent findings that stretching of elastin induces an increase in the binding off rate of elastase to elastin as well as unfolds hidden binding sites along the fiber. We argue that these events can initiate a positive feedback loop which generates slow avalanches of breakdown that eventually give rise to the relentless progression of emphysema. We propose that combining modeling at various length scales with corresponding biological assays, imaging and mechanics data will provide new insight into the progressive nature of emphysema. Such approaches will have the potential to contribute to resolving many of the outstanding issues which in turn may lead to the amelioration or perhaps the treatment of emphysema in the future." @default.
• W2074535177 created "2016-06-24" @default.
• W2074535177 creator A5016263229 @default.
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• W2074535177 date "2012-08-01" @default.
• W2074535177 modified "2023-09-29" @default.
• W2074535177 title "Mechanical failure, stress redistribution, elastase activity and binding site availability on elastin during the progression of emphysema" @default.
• W2074535177 cites W1482666535 @default.
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• W2074535177 cites W1662007645 @default.
• W2074535177 cites W1713255618 @default.
• W2074535177 cites W1747867097 @default.
• W2074535177 cites W1780521007 @default.
• W2074535177 cites W1825267111 @default.
• W2074535177 cites W1890119853 @default.
• W2074535177 cites W1910224821 @default.
• W2074535177 cites W1954721554 @default.
• W2074535177 cites W1966871331 @default.
• W2074535177 cites W1970911936 @default.
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• W2074535177 cites W1978330686 @default.
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• W2074535177 cites W1985675398 @default.
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• W2074535177 doi "https://doi.org/10.1016/j.pupt.2011.04.027" @default.
• W2074535177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21514397" @default.
• W2074535177 hasPublicationYear "2012" @default.
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