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- W2074549488 abstract "In contrast to all other oestrogens examined thus far oestriol hemisuccinate (12 mg/day) did not prevent bone loss in 28 postmenopausal women. The average bone loss, however, was somewhat less than expected from placebo studies, while the bone loss achieved by a group taking 4-6 mg/day was equal to that achieved by previous placebo groups. To be an effective agent for prevention of post-menopausal osteoporosis oestriol would have to be prescribed in daily doses considerably in excess of 12 mg.Studies have shown that estrogen therapy is useful in preventing bone loss, osteoporosis, in postmenopausal women. Long-term estrogen therapy, however, may be associated with an increased incidence of endometrial carcinoma. To be effective against bone loss, the therapy would have to be continued for a long time. A double-blind study was conducted to determine whether estriol, which has weaker effects on the endometrium, at relatively low doses could be used to retard osteoporosis in postmenopausal women. The estriol, at 4mg daily, was ineffective in controlling postmenopausal symptoms; 35% of the patients required a 14 mg-dose, and 5 patients were dissatisfied even with that doage. In addition, the 12 mg-dose did not prevent bone loss, which continued at a rate only slightly lower than for patients on placebo therapy. It is likely that a higher dosage would be more effective, but would cause the potential endometrial effects. Laboratory procedures involved in the study are outlined and results are graphed." @default.
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- W2074549488 date "1979-06-01" @default.
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- W2074549488 title "Bone loss during oestriol therapy in postmenopausal women" @default.
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- W2074549488 doi "https://doi.org/10.1016/0378-5122(79)90018-5" @default.
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