FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074551970> ?p ?o ?g. }

• W2074551970 endingPage "e10685" @default.
• W2074551970 startingPage "e10685" @default.
• W2074551970 abstract "Background Clinically protective malaria vaccines consistently fail to protect adults and children in endemic settings, and at best only partially protect infants. Methodology/Principal Findings We identify and evaluate 1916 immunization studies between 1965-February 2010, and exclude partially or nonprotective results to find 177 completely protective immunization experiments. Detailed reexamination reveals an unexpectedly mundane basis for selective vaccine failure: live malaria parasites in the skin inhibit vaccine function. We next show published molecular and cellular data support a testable, novel model where parasite-host interactions in the skin induce malaria-specific regulatory T cells, and subvert early antigen-specific immunity to parasite-specific immunotolerance. This ensures infection and tolerance to reinfection. Exposure to Plasmodium-infected mosquito bites therefore systematically triggers immunosuppression of endemic vaccine-elicited responses. The extensive vaccine trial data solidly substantiate this model experimentally. Conclusions/Significance We conclude skinstage-initiated immunosuppression, unassociated with bloodstage parasites, systematically blocks vaccine function in the field. Our model exposes novel molecular and procedural strategies to significantly and quickly increase protective efficacy in both pipeline and currently ineffective malaria vaccines, and forces fundamental reassessment of central precepts determining vaccine development. This has major implications for accelerated local eliminations of malaria, and significantly increases potential for eradication." @default.
• W2074551970 created "2016-06-24" @default.
• W2074551970 creator A5042625538 @default.
• W2074551970 creator A5071824605 @default.
• W2074551970 creator A5082358386 @default.
• W2074551970 date "2010-05-19" @default.
• W2074551970 modified "2023-10-14" @default.
• W2074551970 title "Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model" @default.
• W2074551970 cites W100984399 @default.
• W2074551970 cites W115870257 @default.
• W2074551970 cites W1245938035 @default.
• W2074551970 cites W1489581869 @default.
• W2074551970 cites W1491553594 @default.
• W2074551970 cites W1494573187 @default.
• W2074551970 cites W1494583193 @default.
• W2074551970 cites W1514051866 @default.
• W2074551970 cites W1514855317 @default.
• W2074551970 cites W1523800390 @default.
• W2074551970 cites W1525863788 @default.
• W2074551970 cites W1526621387 @default.
• W2074551970 cites W1529036199 @default.
• W2074551970 cites W1530997192 @default.
• W2074551970 cites W1532851064 @default.
• W2074551970 cites W1537342340 @default.
• W2074551970 cites W1540975618 @default.
• W2074551970 cites W1549285889 @default.
• W2074551970 cites W1553821274 @default.
• W2074551970 cites W1560686156 @default.
• W2074551970 cites W1564082849 @default.
• W2074551970 cites W1565131888 @default.
• W2074551970 cites W1571234694 @default.
• W2074551970 cites W1576644001 @default.
• W2074551970 cites W1577391598 @default.
• W2074551970 cites W1583657584 @default.
• W2074551970 cites W1584352387 @default.
• W2074551970 cites W1586942665 @default.
• W2074551970 cites W1588145372 @default.
• W2074551970 cites W1595024798 @default.
• W2074551970 cites W1597425997 @default.
• W2074551970 cites W1600407489 @default.
• W2074551970 cites W1601065475 @default.
• W2074551970 cites W1603402405 @default.
• W2074551970 cites W1606480448 @default.
• W2074551970 cites W1627966435 @default.
• W2074551970 cites W1629184759 @default.
• W2074551970 cites W1631749582 @default.
• W2074551970 cites W1639307070 @default.
• W2074551970 cites W1647467702 @default.
• W2074551970 cites W1648233548 @default.
• W2074551970 cites W1675980360 @default.
• W2074551970 cites W1787048953 @default.
• W2074551970 cites W1792086855 @default.
• W2074551970 cites W1817328855 @default.
• W2074551970 cites W1871729670 @default.
• W2074551970 cites W1890967788 @default.
• W2074551970 cites W1904140959 @default.
• W2074551970 cites W1909391377 @default.
• W2074551970 cites W1919460633 @default.
• W2074551970 cites W1920980936 @default.
• W2074551970 cites W1923914313 @default.
• W2074551970 cites W1937155133 @default.
• W2074551970 cites W1941463571 @default.
• W2074551970 cites W1956798988 @default.
• W2074551970 cites W1958130795 @default.
• W2074551970 cites W1962021264 @default.
• W2074551970 cites W1963295152 @default.
• W2074551970 cites W1964640851 @default.
• W2074551970 cites W1965543649 @default.
• W2074551970 cites W1966221413 @default.
• W2074551970 cites W1966320807 @default.
• W2074551970 cites W1966795940 @default.
• W2074551970 cites W1967015536 @default.
• W2074551970 cites W1968047349 @default.
• W2074551970 cites W1968952839 @default.
• W2074551970 cites W1969126514 @default.
• W2074551970 cites W1971420166 @default.
• W2074551970 cites W1972513959 @default.
• W2074551970 cites W1972867498 @default.
• W2074551970 cites W1973200069 @default.
• W2074551970 cites W1973757441 @default.
• W2074551970 cites W1973990584 @default.
• W2074551970 cites W1974508346 @default.
• W2074551970 cites W1974673196 @default.
• W2074551970 cites W1975755712 @default.
• W2074551970 cites W1976619878 @default.
• W2074551970 cites W1978171344 @default.
• W2074551970 cites W1978265345 @default.
• W2074551970 cites W1979346865 @default.
• W2074551970 cites W1980463883 @default.
• W2074551970 cites W1980690619 @default.
• W2074551970 cites W1980780108 @default.
• W2074551970 cites W1981521423 @default.
• W2074551970 cites W1981681516 @default.
• W2074551970 cites W1984824507 @default.
• W2074551970 cites W1985158166 @default.
• W2074551970 cites W1985243017 @default.
• W2074551970 cites W1985390439 @default.
• W2074551970 cites W1985413676 @default.

• next