FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074561036> ?p ?o ?g. }

• W2074561036 endingPage "259" @default.
• W2074561036 startingPage "252" @default.
• W2074561036 abstract "In previous studies, we have reported that PGF2alpha stimulates phosphoinositide hydrolysis by phospholipase C and phosphatidylcholine hydrolysis by phospholipase D through heterotrimeric GTP-binding protein in osteoblast-like MC3T3-E1 cells, and that PGF2alpha and PGE1 induce interleukin-6 (IL-6) synthesis via activation of protein kinase C and protein kinase A, respectively. In the present study, we investigated the effect of tiludronate, a bisphosphonate known to inhibit bone resorption, on the PGF2alpha- and PGE1-induced IL-6 synthesis in these cells. Tiludronate significantly suppressed the PGF2alpha-induced IL-6 secretion in a dose-dependent manner in the range between 0.1 and 30 microM. However, the IL-6 secretion induced by PGE1 or (Bu)2cAMP was hardly affected by tiludronate. The choline formation induced by PGF2alpha was reduced by tiludronate dose-dependently in the range between 0.1 and 30 microM. On the contrary, tiludronate had no effect on PGF2alpha-induced formation of inositol phosphates. Tiludronate suppressed the choline formation induced by NaF, known as an activator of heterotrimeric GTP-binding protein. However, tiludronate had little effect on the formation of choline induced by TPA, a protein kinase C activator. Tiludronate significantly inhibited the NaF-induced IL-6 secretion in human osteoblastic osteosarcoma Saos-2 cells. These results strongly suggest that tiludronate inhibits PGF2alpha-induced IL-6 synthesis via suppression of phosphatidylcholine-hydrolyzing phospholipase D activation in osteoblasts, and that the inhibitory effect is exerted at the point between heterotrimeric GTP-binding protein and phospholipase D." @default.
• W2074561036 created "2016-06-24" @default.
• W2074561036 creator A5025863828 @default.
• W2074561036 creator A5055679307 @default.
• W2074561036 creator A5071595251 @default.
• W2074561036 creator A5083502334 @default.
• W2074561036 date "1998-06-01" @default.
• W2074561036 modified "2023-09-30" @default.
• W2074561036 title "Tiludronate inhibits interleukin-6 synthesis in osteoblasts: Inhibition of phospholipase D activation in MC3T3-E1 cells" @default.
• W2074561036 cites W1245295209 @default.
• W2074561036 cites W1508152421 @default.
• W2074561036 cites W1802980406 @default.
• W2074561036 cites W1855737037 @default.
• W2074561036 cites W1904321711 @default.
• W2074561036 cites W1917885463 @default.
• W2074561036 cites W1964839077 @default.
• W2074561036 cites W1968418396 @default.
• W2074561036 cites W1987825554 @default.
• W2074561036 cites W1988668160 @default.
• W2074561036 cites W1991027949 @default.
• W2074561036 cites W1991861396 @default.
• W2074561036 cites W1992479729 @default.
• W2074561036 cites W1996898338 @default.
• W2074561036 cites W2007246198 @default.
• W2074561036 cites W2025440698 @default.
• W2074561036 cites W2030989965 @default.
• W2074561036 cites W2041451989 @default.
• W2074561036 cites W2041664976 @default.
• W2074561036 cites W2043175126 @default.
• W2074561036 cites W2045747724 @default.
• W2074561036 cites W2050268374 @default.
• W2074561036 cites W2050858140 @default.
• W2074561036 cites W2053201692 @default.
• W2074561036 cites W2070370334 @default.
• W2074561036 cites W2080875376 @default.
• W2074561036 cites W2084152511 @default.
• W2074561036 cites W2090402759 @default.
• W2074561036 cites W2103796326 @default.
• W2074561036 cites W2104161119 @default.
• W2074561036 cites W2106142458 @default.
• W2074561036 cites W2121436732 @default.
• W2074561036 cites W2121955451 @default.
• W2074561036 cites W2125168145 @default.
• W2074561036 cites W2135392289 @default.
• W2074561036 cites W2146200346 @default.
• W2074561036 cites W2146544146 @default.
• W2074561036 cites W2155728216 @default.
• W2074561036 cites W2321505964 @default.
• W2074561036 cites W29795379 @default.
• W2074561036 cites W63256203 @default.
• W2074561036 doi "https://doi.org/10.1002/(sici)1097-4644(19980601)69:3<252::aid-jcb3>3.0.co;2-q" @default.
• W2074561036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9581864" @default.
• W2074561036 hasPublicationYear "1998" @default.
• W2074561036 type Work @default.
• W2074561036 sameAs 2074561036 @default.
• W2074561036 citedByCount "21" @default.
• W2074561036 countsByYear W20745610362014 @default.
• W2074561036 countsByYear W20745610362017 @default.
• W2074561036 countsByYear W20745610362018 @default.
• W2074561036 countsByYear W20745610362020 @default.
• W2074561036 crossrefType "journal-article" @default.
• W2074561036 hasAuthorship W2074561036A5025863828 @default.
• W2074561036 hasAuthorship W2074561036A5055679307 @default.
• W2074561036 hasAuthorship W2074561036A5071595251 @default.
• W2074561036 hasAuthorship W2074561036A5083502334 @default.
• W2074561036 hasConcept C126322002 @default.
• W2074561036 hasConcept C12927208 @default.
• W2074561036 hasConcept C134018914 @default.
• W2074561036 hasConcept C139407321 @default.
• W2074561036 hasConcept C170493617 @default.
• W2074561036 hasConcept C181199279 @default.
• W2074561036 hasConcept C184235292 @default.
• W2074561036 hasConcept C185592680 @default.
• W2074561036 hasConcept C195794163 @default.
• W2074561036 hasConcept C2778597717 @default.
• W2074561036 hasConcept C55493867 @default.
• W2074561036 hasConcept C6182249 @default.
• W2074561036 hasConcept C71924100 @default.
• W2074561036 hasConcept C80631254 @default.
• W2074561036 hasConcept C86803240 @default.
• W2074561036 hasConceptScore W2074561036C126322002 @default.
• W2074561036 hasConceptScore W2074561036C12927208 @default.
• W2074561036 hasConceptScore W2074561036C134018914 @default.
• W2074561036 hasConceptScore W2074561036C139407321 @default.
• W2074561036 hasConceptScore W2074561036C170493617 @default.
• W2074561036 hasConceptScore W2074561036C181199279 @default.
• W2074561036 hasConceptScore W2074561036C184235292 @default.
• W2074561036 hasConceptScore W2074561036C185592680 @default.
• W2074561036 hasConceptScore W2074561036C195794163 @default.
• W2074561036 hasConceptScore W2074561036C2778597717 @default.
• W2074561036 hasConceptScore W2074561036C55493867 @default.
• W2074561036 hasConceptScore W2074561036C6182249 @default.
• W2074561036 hasConceptScore W2074561036C71924100 @default.
• W2074561036 hasConceptScore W2074561036C80631254 @default.
• W2074561036 hasConceptScore W2074561036C86803240 @default.
• W2074561036 hasIssue "3" @default.
• W2074561036 hasLocation W20745610361 @default.
• W2074561036 hasLocation W20745610362 @default.

• next