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- W2074563039 abstract "Treatment with Aldrin, an organochlorine insecticide, for 13 and 26 days caused suppression of 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxysteroid dehydrogenase (17β-HSD) activities, along with accumulation of cholesterol in the testicular tissues of adult rats. The same treatment also resulted in a reduction in the nuclear diameter of Leydig cells (LCND) and diameter of seminiferous tubules. A decrease in the weight of testes, seminal vesicles and ventral prostate was also noted. HCG administration in the long-term (26 days) treatment restored the steroidogenic enzymes activity and the nuclear diameter of the Leydig cells. It also reduced the accumulation of tissue cholesterol towards the vehicle-injected controls. The inhibition of steroidogenesis in the testes possibly reflects a decrease in pituitary gonadotrophin release after the treatment with Aldrin." @default.
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- W2074563039 date "1988-01-01" @default.
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- W2074563039 title "Suppression of testicular steroidogenesis in rats by the organochlorine insecticide Aldrin" @default.
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- W2074563039 doi "https://doi.org/10.1016/0269-7491(88)90198-4" @default.
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