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• W2074564345 abstract "The aim of this study was to investigate extrusion–spheronization pelletization for preparing pH-sensitive matrix pellets for colon-specific drug delivery. The effects of three independent variables (amounts of Eudragit™ S, citric acid and spheronizing time) on pellet size, shape (roundness and aspect ratio), and drug release were studied with central composite design. The pellets contained ibuprofen as a model drug, citric acid as a pH-adjusting agent, Eudragit™ S as a pH-sensitive binder and microcrystalline cellulose (MCC). The pellets were prepared with Nica extrusion–spheronizing equipment and subsequently enteric-coated using an air-suspension technique. Eudragit™ S as a pH-sensitive matrix former in pellets increased the pellet size and influenced pellet roundness. In small amounts Eudragit™ S increased pellet roundness but in larger amounts pellet roundness was reduced. Citric acid promoted the pelletization process resulting in a narrower area distribution. The pH-sensitive matrix pellet failed to delay the drug release. The combination of citric acid and enteric coating, however, delayed the drug release for 15 min in a pH 7.4 phosphate buffer." @default.
• W2074564345 created "2016-06-24" @default.
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• W2074564345 date "2000-04-01" @default.
• W2074564345 modified "2023-09-25" @default.
• W2074564345 title "Extrusion–spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery" @default.
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• W2074564345 doi "https://doi.org/10.1016/s0378-5173(00)00382-3" @default.
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