Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074564881> ?p ?o ?g. }
- W2074564881 endingPage "288" @default.
- W2074564881 startingPage "279" @default.
- W2074564881 abstract "Histatins are salivary proteins found and expressed in human salivary glands. They play a role in the non-immune system of antimicrobial defense, for instance, against Candida albicans. The transcriptional regulatory sequences of the histatin gene, HIS1, have remained obscure for a long time. Here, we cloned the putative promoter from human genomic DNA and tested it in a luciferase reporter system. This promoter is much more active in salivary gland cells than in other cell types. Analysis of deletion mutants revealed that the region encompassing −2254 to −1748 is a strong positive transcriptional element, and its functional core sequence (termed HTN27 box) works in correct and reverse orientations in synergy with downstream sequences, the region spanning −680 to +28 and a proximal promoter. The plus single-stranded HTN27 box is specifically bound by a 100 kDa protein that is present in HSG cells, but not in HeLa cells. These findings indicate that the regulation of the histatin gene expression may be intricate, and it seems to have a cell-type preference in the salivary gland cells." @default.
- W2074564881 created "2016-06-24" @default.
- W2074564881 creator A5008612804 @default.
- W2074564881 creator A5017951685 @default.
- W2074564881 creator A5044149306 @default.
- W2074564881 creator A5067777923 @default.
- W2074564881 creator A5070240135 @default.
- W2074564881 creator A5075959698 @default.
- W2074564881 creator A5079724607 @default.
- W2074564881 date "2009-01-04" @default.
- W2074564881 modified "2023-09-27" @default.
- W2074564881 title "Transcriptional Regulation of the Salivary Histatin Gene: Finding of a Strong Positive Regulatory Element and Its Binding Protein" @default.
- W2074564881 cites W112486650 @default.
- W2074564881 cites W1833478303 @default.
- W2074564881 cites W1884640218 @default.
- W2074564881 cites W1974349997 @default.
- W2074564881 cites W1978670381 @default.
- W2074564881 cites W1983898400 @default.
- W2074564881 cites W1984706012 @default.
- W2074564881 cites W1989272070 @default.
- W2074564881 cites W1989516264 @default.
- W2074564881 cites W1992376704 @default.
- W2074564881 cites W2000053133 @default.
- W2074564881 cites W2000261494 @default.
- W2074564881 cites W2005866384 @default.
- W2074564881 cites W2010525367 @default.
- W2074564881 cites W2010999630 @default.
- W2074564881 cites W2041315844 @default.
- W2074564881 cites W2044047843 @default.
- W2074564881 cites W2049877956 @default.
- W2074564881 cites W2055555006 @default.
- W2074564881 cites W2061102119 @default.
- W2074564881 cites W2065847024 @default.
- W2074564881 cites W2066666287 @default.
- W2074564881 cites W2068010992 @default.
- W2074564881 cites W2068577315 @default.
- W2074564881 cites W2076058856 @default.
- W2074564881 cites W2082802847 @default.
- W2074564881 cites W2091874747 @default.
- W2074564881 cites W2092507621 @default.
- W2074564881 cites W2103047766 @default.
- W2074564881 cites W2106426214 @default.
- W2074564881 cites W2115372426 @default.
- W2074564881 cites W2129547737 @default.
- W2074564881 cites W2144274119 @default.
- W2074564881 cites W2146550728 @default.
- W2074564881 cites W2153764989 @default.
- W2074564881 cites W2156426445 @default.
- W2074564881 cites W2156874779 @default.
- W2074564881 cites W2159490085 @default.
- W2074564881 doi "https://doi.org/10.1093/jb/mvn165" @default.
- W2074564881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19060311" @default.
- W2074564881 hasPublicationYear "2009" @default.
- W2074564881 type Work @default.
- W2074564881 sameAs 2074564881 @default.
- W2074564881 citedByCount "8" @default.
- W2074564881 countsByYear W20745648812012 @default.
- W2074564881 countsByYear W20745648812013 @default.
- W2074564881 countsByYear W20745648812014 @default.
- W2074564881 countsByYear W20745648812019 @default.
- W2074564881 countsByYear W20745648812022 @default.
- W2074564881 crossrefType "journal-article" @default.
- W2074564881 hasAuthorship W2074564881A5008612804 @default.
- W2074564881 hasAuthorship W2074564881A5017951685 @default.
- W2074564881 hasAuthorship W2074564881A5044149306 @default.
- W2074564881 hasAuthorship W2074564881A5067777923 @default.
- W2074564881 hasAuthorship W2074564881A5070240135 @default.
- W2074564881 hasAuthorship W2074564881A5075959698 @default.
- W2074564881 hasAuthorship W2074564881A5079724607 @default.
- W2074564881 hasConcept C101762097 @default.
- W2074564881 hasConcept C104317684 @default.
- W2074564881 hasConcept C111335760 @default.
- W2074564881 hasConcept C150194340 @default.
- W2074564881 hasConcept C153911025 @default.
- W2074564881 hasConcept C161733203 @default.
- W2074564881 hasConcept C165864922 @default.
- W2074564881 hasConcept C27153228 @default.
- W2074564881 hasConcept C2778937882 @default.
- W2074564881 hasConcept C2780917455 @default.
- W2074564881 hasConcept C54009773 @default.
- W2074564881 hasConcept C54355233 @default.
- W2074564881 hasConcept C55493867 @default.
- W2074564881 hasConcept C86803240 @default.
- W2074564881 hasConcept C95444343 @default.
- W2074564881 hasConceptScore W2074564881C101762097 @default.
- W2074564881 hasConceptScore W2074564881C104317684 @default.
- W2074564881 hasConceptScore W2074564881C111335760 @default.
- W2074564881 hasConceptScore W2074564881C150194340 @default.
- W2074564881 hasConceptScore W2074564881C153911025 @default.
- W2074564881 hasConceptScore W2074564881C161733203 @default.
- W2074564881 hasConceptScore W2074564881C165864922 @default.
- W2074564881 hasConceptScore W2074564881C27153228 @default.
- W2074564881 hasConceptScore W2074564881C2778937882 @default.
- W2074564881 hasConceptScore W2074564881C2780917455 @default.
- W2074564881 hasConceptScore W2074564881C54009773 @default.
- W2074564881 hasConceptScore W2074564881C54355233 @default.
- W2074564881 hasConceptScore W2074564881C55493867 @default.
- W2074564881 hasConceptScore W2074564881C86803240 @default.