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• W2074568813 abstract "The actions of exogenously applied ATP were investigated with the whole‐cell patch clamp method in single cells isolated from guinea‐pig urinary bladder with a modified concentration jump technique. Rapid application of ATP (threshold ca. 100 n m ) depolarized the cell membrane with superimposition of action potentials which was followed by transient hyperpolarization. In the presence of D600, the amplitude of the ATP‐induced depolarization was a function of the ATP concentration (EC 50 :0.5‐1 μ m ). ATP activated a dose‐dependent inward current with a short latency (18 ms with 10 μ m ATP; measured as the time between the start of application and 10% of the peak). The relationship of the peak current versus ATP concentration was well fitted by a Michaelis‐Menten equation with a Hill coefficient (n) of 1.7 and a dissociation constant ( K d ) of 2.3 μ m . The current desensitized rapidly and the time course of desensitization was a function of the ATP concentration and could be fitted by two exponentials. The reversal potential of the ATP‐activated current was near 0 mV. Replacement of extracellular Na by other monovalent or divalent cations indicated that the current flows through nonselective cation channels. α,β‐Methylene ATP also produced a dose‐dependent inward current but was less potent than ATP (n: 1.6, K d : 10.4 μ m ). α,β‐Methylene ATP blocked the response to ATP by desensitization of the receptor. α,β‐Methylene ATP was 50–100 times more potent than ATP at eliciting a contractile response of strips of detrusor smooth muscle. The relevance of the above results to the possible role of ATP as the fast excitatory transmitter is discussed." @default.
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• W2074568813 date "1990-07-01" @default.
• W2074568813 modified "2023-10-17" @default.
• W2074568813 title "The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder" @default.
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• W2074568813 doi "https://doi.org/10.1111/j.1476-5381.1990.tb15856.x" @default.
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