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- W2074570115 abstract "Parenteral nutrition (TPN) is vital in the nutritional support of infants with surgical GI tract lesions. Rat studies demonstrate decreased small bowel (SB) mucosal enzymes and intestinal atrophy. We studied the effects of TPN during the phase of rapid intestinal growth and development in piglets. Groups of three 6 wk old weaned piglet littermates received for 3 wks an amino acid(8gm/kg/day), glucose(35gm/kg/day), fat(2.5gm/kg/day) solution intravenously(TPN) or by gastrostomy(GF) or were given chow at an equivalent caloric value. No differences were noted in avg weight gain(13–15gm/kg/day), total serum protein(4.5-4.8gm/dl), BUN (9-12mg/dl) and Hct(30-35%). Comparing the TPN and GF to the chow-fed animals, there were: 1) decreased growth of the stomach, SB and pancreas, 2) decreased SB mucosal disaccharidases. The TPN group compared to baseline measurements demonstrated 1) decreased SB weight and length, 2) decreased pancreatic weight. Histology of SB mucosa in TPN animals showed decreased mucosal depth, villous height, crypt depth and epithelial cell number to the mid-villous area. These findings suggest 1) stomach, SB and pancreatic growth are dependent on route of administration and composition of diet 2) SB mucosa and pancreas atrophy in young piglets maintained on TPN 3) intestinal disaccharidases are decreased in the proximal SB in piglets maintained on both intravenous and intragastric infusion of a TPN solution." @default.
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- W2074570115 date "1985-04-01" @default.
- W2074570115 modified "2023-10-17" @default.
- W2074570115 title "657 EFFECTS OF TPN ON INTESTINAL DEVELOPMENT" @default.
- W2074570115 doi "https://doi.org/10.1203/00006450-198504000-00687" @default.
- W2074570115 hasPublicationYear "1985" @default.
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