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- W2074573984 abstract "Compare early bioavailability of rectal, effervescent oral, and i.v. paracetamol. Five groups of N = 7 patients received 1 or 2 g paracetamol orally or rectally or 1 g i.v. immediately after day surgery. Paracetamol concentrations taken after 20, 40 and 80 min. Median plasma paracetamol concentrations for 1 versus 2 g effervescents were 78 (25–114) versus 108 (95–146) μmol L−1 at 80 min and 16 (9–30) versus 17 (10–30) μmol L−1 for 1 versus 2 g suppositories. Paracetamol i.v. gave median 97 (77–135) μmol L−1 after 40 min. Only intravenously and 2 g effervescent paracetamol gave therapeutic concentrations during the period studied." @default.
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- W2074573984 date "2005-05-01" @default.
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- W2074573984 title "Early bioavailability in day surgery: a comparison between orally, rectally, and intravenously administered paracetamol" @default.
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- W2074573984 doi "https://doi.org/10.1016/j.ambsur.2005.02.001" @default.
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